High incidence of triploidy in in-vitro fertilized oocytes from a patient with a previous history of recurrent gestational trophoblastic disease

• Published in: Human reproduction (Oxford) Vol. 11; no. 7; pp. 1529 - 1532
• Main Authors: Lubna, Pal, Toth, T.L., Leykin, L., Isaacson, K.B.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.07.1996
• Subjects: Adult; Biological and medical sciences; Cytoplasm; Diseases of mother, fetus and pregnancy; Female; Fertilization in Vitro - methods; Gynecology. Andrology. Obstetrics; Humans; Hydatidiform Mole - genetics; Male; Medical sciences; Microinjections; Polyploidy; Pregnancy; Pregnancy. Fetus. Placenta; Recurrence; Spermatozoa; Zygote - ultrastructure; recurrent GTD; triploid; fertilization; gestational trophoblastic disease; Human; Relapse; Trophoblaste pathology; Pregnancy disorders; Hydatidiform mole; Fecundation; Placenta diseases; In vitro; Case study; Association; Placenta; Tumor; Female; Triploidy
• ISSN: 0268-1161; 1460-2350
• DOI: 10.1093/oxfordjournals.humrep.a019432

Abstract The patient described has a history of recurrent gestational trophoblastic disease following spontaneous conception. She subsequently underwent two cycles of in-vitro fertilization (IVF) for management of infertility related to tubal obstruction. IVF of the oocytes retrieved showed a significantly high incidence of abnormal fertilization resulting in the development of triploid embryos. This report explores the possible association of an oocyte defect predisposing to abnormal fertilization, resulting in a high incidence of triplold embryos. Since the development of partial hydatidi form moles is related to the origin of triploidy, this phenomenon is suggested to explain the occurrence of recurrent trophoblastic disease in this patient. We propose the use of intracytoplasmic sperm injection (ICSI) as a therapeutic option to minimize the incidence of triploidy in future IVF cycles; donor oocyte WF would be another alternative.