Implication of changes in xanthine oxidase activity following hemodialysis

• Published in: BMC nephrology Vol. 24; no. 1; pp. 13 - 8
• Main Authors: Fujioka, Hayato, Koike, Tsutomu, Imamura, Teruhiko, Kakeshita, Kota, Yamazaki, Hidenori, Kinugawa, Koichiro
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.01.2023; BioMed Central; BMC
• Subjects: Aged; Blood Pressure; Care and treatment; Chronic kidney failure; Complications and side effects; Female; Health aspects; Heart; Hemodialysis; Hemodynamics; Humans; Male; Measurement; Oxidative Stress - physiology; Oxidoreductases; Patient outcomes; Prognosis; Renal Dialysis; Uremia; Xanthine oxidase; Xanthine Oxidase - metabolism; Japan; Xanthine oxidase; Hemodynamics; Uremia; Hemodialysis
• ISSN: 1471-2369; 1471-2369
• DOI: 10.1186/s12882-023-03062-z

Xanthine oxidase activity has a key role in the development of oxidative stress and progression of cardiovascular diseases. However, the change of xanthine oxidase activity following hemodialysis and its prognostic impact remain uncertain. We prospectively included hemodialysis patients who did not take any anti-hyperuricemic agents and measured their xanthine oxidase activity before and after the index hemodialysis. The impact of change in xanthine oxidase activity during hemodialysis on cardiovascular death were investigated. A total of 46 patients (median 72 years old, 29 men) were included. During hemodialysis, a common logarithm of xanthine oxidase activity decreased significantly from 1.16 (0.94, 1.27) to 1.03 (0.80, 1.20) (p < 0.01). Of them, xanthine oxidase activity remained unchanged or increased in 16 patients, who had a greater decrease in blood pressure and more hemoconcentration compared with others. Two-year survival from cardiovascular death was not significantly stratified by the changes in xanthine oxidase activity (p = 0.43). During hemodialysis, xanthine oxidase activity decreased among the overall cohort, whereas some patients experienced its increases, which might be associated with hypotension and hemoconcentration during hemodialysis. Further larger-scale studies are required to validate our findings and find clinical implication of change in xanthine oxidase activity during hemodialysis.