A New Generation of Treatments for Itch

For decades, antihistamines have been the mainstay of treatment for chronic pruritus, yet they often only work by making patients drowsy and forgetful of their itch. A new era of antipruritic drugs is quickly approaching, presenting more effective treatments for patients suffering from chronic itch....

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Bibliographic Details
Published inActa dermato-venereologica Vol. 100; no. 2; pp. adv00027 - 45
Main Authors Fowler, Emilie, Yosipovitch, Gil
Format Journal Article
LanguageEnglish
Published Sweden Society for Publication of Acta Dermato-Venereologica 01.01.2020
Medical Journals Sweden
Subjects
antipruritics
cytokines
pruritus
Review
unmyelinated nerve fibers
pruritus
cytokines
unmyelinated nerve fibers
antipruritics
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Summary:For decades, antihistamines have been the mainstay of treatment for chronic pruritus, yet they often only work by making patients drowsy and forgetful of their itch. A new era of antipruritic drugs is quickly approaching, presenting more effective treatments for patients suffering from chronic itch. Several treatments have been developed targeting specific receptors in the nervous system, such as the transient receptor potential channels, sodium channels, neurokinin-1 receptors, opioid receptors, and many more. Additionally, antipruritic therapies developed to work on the immune system have become more targeted, leading to greater safety and efficacy measures. These include crisaborole, several interleukin antagonists, and janus kinase inhibitors. The promising results presented with these new antipruritic therapies allow physicians to be better equipped to treat their itchy patients.
ISSN:0001-5555
1651-2057
DOI:10.2340/00015555-3347