Glutathione Reductase Activity in Serum and Liver Tissue of Human and Rat with Hepatic Damage

Glutathione reductase activity of both serum and liver tissue homogenates was measured in normal controls and in cases of hepatic parenchymatous diseases, and the results were compared with those from animal experiments in which hepatic damage was produced by CCl4 injection. Glutathione reductase sh...

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Published inThe Tohoku Journal of Experimental Medicine Vol. 116; no. 2; pp. 127 - 132
Main Authors KUMATA, HIROKATSU, WAKUI, KAZUO, SUZUKI, HIROSHI, SUGAWARA, TAKEHISA, LIM, INSU, OTSUKI, MASAO, OZEKI, TSUNEO, MIURA, KIYOMI, YAMAGATA, SHOICHI
Format Journal Article
LanguageEnglish
Published Japan Tohoku University Medical Press 01.01.1975
Subjects
Acute Disease
Alanine Transaminase - blood
Alkaline Phosphatase - metabolism
Animals
Aspartate Aminotransferases - metabolism
Carbon Tetrachloride Poisoning - enzymology
Chronic Disease
glutathione reductase
Glutathione Reductase - metabolism
Hepatitis - enzymology
Humans
Liver - enzymology
Liver Cirrhosis - enzymology
Liver Diseases - enzymology
liver homogenates
Male
parenchymatous liver diseases
Rats
serum
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Summary:Glutathione reductase activity of both serum and liver tissue homogenates was measured in normal controls and in cases of hepatic parenchymatous diseases, and the results were compared with those from animal experiments in which hepatic damage was produced by CCl4 injection. Glutathione reductase showed a different attitude from those of transaminases and alkaline phosphatases under these clinical and experimental conditions. Glutathione reductase activity increased in both serum and liver in patients with hepatic damage, and this increase occurred earlier than the changes in alkaline phosphatase activity.
ISSN:0040-8727
1349-3329
DOI:10.1620/tjem.116.127