Lack of association of SLC1A1 variants with schizophrenia in Chinese Han population

Abstract In this study, we analyzed four single nucleotide polymorphisms (SNPs) (rs10491734, rs2228622, rs301430 and rs301443) of the solute carrier family 1 gene ( SLC1A1 ) in a set of 616 schizophrenia patients and 638 matched healthy controls of Han Chinese descent. No significant differences of...

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Published inPsychiatry research Vol. 210; no. 2; pp. 669 - 671
Main Authors Lu, Weihong, Wu, Haisu, Cai, Jun, Wang, Zuowei, Yi, Zhenghui, Yu, Shunying, Fang, Yiru, Zhang, Chen
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier Ireland Ltd 15.12.2013
Elsevier
Subjects
Adult
Adult and adolescent clinical studies
Alleles
Asian Continental Ancestry Group - genetics
Biological and medical sciences
Case-Control Studies
Excitatory Amino Acid Transporter 3 - genetics
Female
Genetic association
Genetic Predisposition to Disease
Genetic Variation
Genotype
Haplotypes
Humans
Male
Medical sciences
Middle Aged
Polymorphism, Single Nucleotide
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - genetics
SLC1A1
Schizophrenia
Genetic association
SLC1A1
Psychosis
Chinese
Genetics
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Summary:Abstract In this study, we analyzed four single nucleotide polymorphisms (SNPs) (rs10491734, rs2228622, rs301430 and rs301443) of the solute carrier family 1 gene ( SLC1A1 ) in a set of 616 schizophrenia patients and 638 matched healthy controls of Han Chinese descent. No significant differences of genotype or allele distribution were identified between the patients and controls. Our data suggest that SLC1A1 is unlikely to be a major susceptibility gene for schizophrenia in Han Chinese.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2013.07.009