The journey of resveratrol from yeast to human

The natural polyphenolic compound resveratrol was first discovered in the 1940s. In the recent years, this compound received renewed interest as several findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie restriction, and regulating longevity in lo...

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Published inAging (Albany, NY.) Vol. 4; no. 3; pp. 146 - 158
Main Authors Timmers, Silvie, Auwerx, Johan, Schrauwen, Patrick
Format Journal Article
LanguageEnglish
Published United States Impact Journals LLC 12.03.2012
Subjects
Aging - metabolism
Animals
Caloric Restriction
Energy Metabolism - drug effects
Enzyme Activation
Enzyme Activators - administration & dosage
Enzyme Activators - pharmacokinetics
Enzyme Activators - therapeutic use
Evidence-Based Medicine
Fungal Proteins - metabolism
Humans
Phosphodiesterase Inhibitors - administration & dosage
Phosphodiesterase Inhibitors - pharmacokinetics
Phosphodiesterase Inhibitors - therapeutic use
Review
Sirtuin 1 - metabolism
Stilbenes - administration & dosage
Stilbenes - pharmacokinetics
Stilbenes - therapeutic use
Yeasts - drug effects
Yeasts - enzymology
Online AccessGet full text
ISSN1945-4589
1945-4589
DOI10.18632/aging.100445

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Abstract The natural polyphenolic compound resveratrol was first discovered in the 1940s. In the recent years, this compound received renewed interest as several findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie restriction, and regulating longevity in lower organisms. Given the worldwide increase in age-related metabolic diseases the beneficial effects of resveratrol on metabolism and healthy aging in humans are currently a topic of intense investigation.
AbstractList The natural polyphenolic compound resveratrol was first discovered in the 1940s. In the recent years, this compound received renewed interest as several findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie restriction, and regulating longevity in lower organisms. Given the worldwide increase in age-related metabolic diseases the beneficial effects of resveratrol on metabolism and healthy aging in humans are currently a topic of intense investigation.
The natural polyphenolic compound resveratrol was first discovered in the 1940s. In the recent years, this compound received renewed interest as several findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie restriction, and regulating longevity in lower organisms. Given the worldwide increase in age-related metabolic diseases the beneficial effects of resveratrol on metabolism and healthy aging in humans are currently a topic of intense investigation.The natural polyphenolic compound resveratrol was first discovered in the 1940s. In the recent years, this compound received renewed interest as several findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie restriction, and regulating longevity in lower organisms. Given the worldwide increase in age-related metabolic diseases the beneficial effects of resveratrol on metabolism and healthy aging in humans are currently a topic of intense investigation.
Author Auwerx, Johan
Timmers, Silvie
Schrauwen, Patrick
AuthorAffiliation 3 Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
2 Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, 6200 Maastricht, The Netherlands
1 Top Institute Food and Nutrition (TIFN), 6700 Wageningen, The Netherlands
AuthorAffiliation_xml – name: 1 Top Institute Food and Nutrition (TIFN), 6700 Wageningen, The Netherlands
– name: 2 Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, 6200 Maastricht, The Netherlands
– name: 3 Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
Author_xml – sequence: 1
  givenname: Silvie
  surname: Timmers
  fullname: Timmers, Silvie
  organization: Top Institute Food and Nutrition (TIFN), 6700 Wageningen, The Netherlands, Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, 6200 Maastricht, The Netherlands
– sequence: 2
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  surname: Auwerx
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  organization: Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
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  givenname: Patrick
  surname: Schrauwen
  fullname: Schrauwen, Patrick
  organization: Top Institute Food and Nutrition (TIFN), 6700 Wageningen, The Netherlands, Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, 6200 Maastricht, The Netherlands
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Snippet The natural polyphenolic compound resveratrol was first discovered in the 1940s. In the recent years, this compound received renewed interest as several...
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StartPage 146
SubjectTerms Aging - metabolism
Animals
Caloric Restriction
Energy Metabolism - drug effects
Enzyme Activation
Enzyme Activators - administration & dosage
Enzyme Activators - pharmacokinetics
Enzyme Activators - therapeutic use
Evidence-Based Medicine
Fungal Proteins - metabolism
Humans
Phosphodiesterase Inhibitors - administration & dosage
Phosphodiesterase Inhibitors - pharmacokinetics
Phosphodiesterase Inhibitors - therapeutic use
Review
Sirtuin 1 - metabolism
Stilbenes - administration & dosage
Stilbenes - pharmacokinetics
Stilbenes - therapeutic use
Yeasts - drug effects
Yeasts - enzymology
Title The journey of resveratrol from yeast to human
URI https://www.ncbi.nlm.nih.gov/pubmed/22436213
https://www.proquest.com/docview/1010488323
https://pubmed.ncbi.nlm.nih.gov/PMC3348475
Volume 4
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