The journey of resveratrol from yeast to human

The natural polyphenolic compound resveratrol was first discovered in the 1940s. In the recent years, this compound received renewed interest as several findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie restriction, and regulating longevity in lo...

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Published inAging (Albany, NY.) Vol. 4; no. 3; pp. 146 - 158
Main Authors Timmers, Silvie, Auwerx, Johan, Schrauwen, Patrick
Format Journal Article
LanguageEnglish
Published United States Impact Journals LLC 12.03.2012
Subjects
Aging - metabolism
Animals
Caloric Restriction
Energy Metabolism - drug effects
Enzyme Activation
Enzyme Activators - administration & dosage
Enzyme Activators - pharmacokinetics
Enzyme Activators - therapeutic use
Evidence-Based Medicine
Fungal Proteins - metabolism
Humans
Phosphodiesterase Inhibitors - administration & dosage
Phosphodiesterase Inhibitors - pharmacokinetics
Phosphodiesterase Inhibitors - therapeutic use
Review
Sirtuin 1 - metabolism
Stilbenes - administration & dosage
Stilbenes - pharmacokinetics
Stilbenes - therapeutic use
Yeasts - drug effects
Yeasts - enzymology
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Summary:The natural polyphenolic compound resveratrol was first discovered in the 1940s. In the recent years, this compound received renewed interest as several findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie restriction, and regulating longevity in lower organisms. Given the worldwide increase in age-related metabolic diseases the beneficial effects of resveratrol on metabolism and healthy aging in humans are currently a topic of intense investigation.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-3
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ISSN:1945-4589
1945-4589
DOI:10.18632/aging.100445