Association of Peripheral Mononuclear Cells Containing Chlamydia Pneumoniae DNA with Acute Coronary Syndrome and Stable Coronary Artery Disease in Japanese Subjects

• Published in: Clinical infectious diseases Vol. 39; no. 3; pp. 366 - 372
• Main Authors: Aso, Nobuko, Tamura, Akira, Kadota, Jun-ichi, Nasu, Masaru
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01.08.2004; University of Chicago Press
• Subjects: Acute coronary syndrome; Aged; Angina, Unstable - microbiology; Atherosclerosis; Biological and medical sciences; Blood; Blood donation; Cardiology. Vascular system; Chlamydia pneumoniae; Chlamydophila Infections - complications; Chlamydophila Infections - epidemiology; Chlamydophila pneumoniae; Chlamydophila pneumoniae - isolation & purification; Coronary artery disease; Coronary Disease - microbiology; Coronary heart disease; DNA; DNA, Bacterial - blood; Endothelial cells; Female; Heart; Humans; Infections; Infectious diseases; Japan - epidemiology; Leukocytes, Mononuclear - microbiology; Major Articles; Male; Medical sciences; Middle Aged; Myocardial Infarction - microbiology; Polymerase Chain Reaction; Prevalence; Reproducibility of Results; Seasons; Asia; Japan; Human; Chlamydia pneumoniae; Prevalence; Nested polymerase chain reaction; Chlamydiaceae; Acute; Coronary artery; Check; Cardiovascular disease; Epidemiology; Coronary heart disease; Japanese; Prevention; Infection; Blood cell; Mononuclear cell; Seasonal variation; DNA; Chlamydiales; Bacteria; Adult; Comparative study
• ISSN: 1058-4838; 1537-6591; 1537-6591
• DOI: 10.1086/422316

To clarify the association of Chlamydia pneumoniae DNA in peripheral blood mononuclear cells (PBMCs) with acute coronary syndrome (ACS) and stable coronary artery disease (CAD) in Japanese adults, touchdown-nested polymerase chain reaction was used to detect the presence of C. pneumoniae DNA. The prevalence of C. pneumoniae DNA in PBMCs was similar in a comparison of 88 patients (52.3%) with ACS, 164 patients (50.0%) with stable CAD, and 88 control subjects (50.0%). Temporal changes in the prevalence of C. pneumoniae DNA in PBMCs were also assessed every 3 months during a 1-year period (n = 59). The prevalence was significantly higher in the first 3-month period (January through March) than in any of the other 3-month periods. In conclusion, the prevalence of C. pneumoniae DNA in PBMCs in patients with ACS or stable CAD was comparable to that in control populations. Furthermore, the presence of circulating C. pneumoniae was strongly associated with seasonal variability.