Miltefosine Treatment of Leishmania major Infection: An Observational Study Involving Dutch Military Personnel Returning from Northern Afghanistan

• Published in: Clinical infectious diseases Vol. 50; no. 1; pp. 80 - 83
• Main Authors: van Thiel, P.P.A.M., Leenstra, T., Kager, P.A., de Vries, H.J., van Vugt, M., van der Meide, W.F., Bart, A., Zeegelaar, J.E., van der Sluis, A., Schallig, H.D.F.H., van Gool, T., Faber, W.R., de Vries, P.J.
• Format: Journal Article
• Language: English
• Published: Oxford The University of Chicago Press 01.01.2010; University of Chicago Press; Oxford University Press
• Subjects: Adult; Adverse effects; Afghanistan; Antimony; Biological and medical sciences; BRIEF REPORTS; Cutaneous leishmaniasis; Female; Human protozoal diseases; Humans; Infections; Infectious diseases; Leishmania major; Leishmania major - isolation & purification; Leishmaniasis; Leishmaniasis, Cutaneous - diagnosis; Leishmaniasis, Cutaneous - drug therapy; Leshmaniasis; Lesions; Male; Medical cures; Medical sciences; Middle Aged; Military Personnel; Netherlands; Parasites; Parasitic diseases; Parasitology; Patients; Phosphorylcholine - adverse effects; Phosphorylcholine - analogs & derivatives; Phosphorylcholine - therapeutic use; Protozoa; Protozoal diseases; Retrospective Studies; Travel; Treatment Outcome; Afghanistan; Netherlands; Asia; Europe; Kinetoplastida; Antineoplastic agent; Protozoa; Protozoal disease; Phospholipid; Parasitosis; Leishmaniasis; Infection; Miltefosine; Imported disease; Treatment; Lysophospholipid; Travel medicine; Leishmania major; Military
• ISSN: 1058-4838; 1537-6591
• DOI: 10.1086/648726

In a retrospective, observational study involving 34 patients with Leishmania major infection, 31 of whom had experienced unsuccessful treatment with intralesional antimony (ilSbv), miltefosine proved effective. Thirty patients experienced cure after receipt of miltefosine, 3 after receipt of additional ilSbv, and 1 after 28 daily intravenous injections of antimony. Temporary diminution of ejaculate volume was reported by 21 patients.