Terpenoids from the Chinese liverwort Odontoschisma grosseverrucosum and their antifungal virulence activity

• Published in: Phytochemistry (Oxford) Vol. 174; pp. 112341 - 112349
• Main Authors: Zhu, Ming-Zhu, Li, Yi, Zhou, Jin-Chuan, Lu, Jing-Hui, Zhu, Rong-Xiu, Qiao, Ya-Nan, Zhang, Jiao-Zhen, Zong, Yan, Wang, Xue, Jin, Xue-Yang, Zhang, Ming, Chang, Wen-Qiang, Chen, Wang, Lou, Hong-Xiang
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.06.2020; Elsevier
• Subjects: adhesion; Anti-virulence; Antifungal Agents; Biochemistry & Molecular Biology; biofilm; Biofilms; Candida albicans; circular dichroism spectroscopy; Fungal Proteins; gene expression; genes; Hepatophyta; Life Sciences & Biomedicine; Liverworts; mosses and liverworts; nuclear magnetic resonance spectroscopy; Odongrossin A−H; Odontoschisma grosseverrucosum Stephani (cephaloziaceae); Plant Sciences; Science & Technology; Terpenes; Terpenoids; transcription (genetics); Virulence; X-ray diffraction; Candida albicans; Odongrossin A−H; Anti-virulence; Odontoschisma grosseverrucosum Stephani (cephaloziaceae); Liverworts; Terpenoids; VIBSANE; MODEL; CANDIDA-ALBICANS; CHEMICAL-CONSTITUENTS; BRYOPHYTES; DITERPENOIDS; AZOLE RESISTANCE; Odongrossin A - H
• ISSN: 0031-9422; 1873-3700; 1873-3700
• DOI: 10.1016/j.phytochem.2020.112341

Eight undescribed terpenoids, namely, odongrossins A−H, together with two known terpenoids were isolated from Odontoschisma grosseverrucosum Stephani (Cephaloziaceae). Their structures were established based on NMR data, electronic circular dichroism (ECD) calculations, and single-crystal X-ray diffraction measurements. Odongrossin A and odongrossin G displayed moderate anti-virulence activities against CDR1-and CDR2-efflux-pump-deficient Candida albicans DSY654. Further investigation of odongrossin A revealed that it inhibited adhesion and biofilm formation on C. albicans DSY654. The results regarding the transcription levels of genes demonstrated that odongrossin A could regulate the expression of genes that are associated with the virulence of C. albicans DSY654. Eight undescribed terpenoids were isolated from O. grosseverrucosum. Odongrossin A displayed antifungal virulence activity. [Display omitted] •Eight undescribed terpenoids were isolated from O. grosseverrucosum.•Structures were determined by extensive spectroscopic analyses.•Odongrossin A displayed antifungal virulence activity.