Prevalence of primary angle-closure disease in retinitis pigmentosa

• Published in: Indian journal of ophthalmology Vol. 70; no. 7; pp. 2449 - 2451
• Main Authors: Pradhan, Zia, Shroff, Sujani, Bansod, Apurva, Poornachandra, B, Shetty, Anisha, Devi, Sathi, Rao, Dhanaraj, Puttaiah, Narendra, Rao, Harsha
• Format: Journal Article
• Language: English
• Published: Mumbai Wolters Kluwer India Pvt. Ltd 01.07.2022; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: Age; Anterior chamber; Electronic medical records; Glaucoma; Heredity; Original; Patients; primary angle-closure disease; Retinitis; Retinitis pigmentosa; Glaucoma; retinitis pigmentosa; primary angle-closure disease
• ISSN: 0301-4738; 1998-3689
• DOI: 10.4103/ijo.IJO_3189_21

Purpose: To determine the prevalence of primary angle-closure disease (PACD) in patients with retinitis pigmentosa (RP). Methods: This was a retrospective review of the electronic medical records of all RP patients over the age of 10 years attending the Genetics Eye Clinic of a tertiary-care hospital during a 7-year period. Information regarding age, gender, vision, refraction, lens, intraocular pressure (IOP), type of RP, and inheritance pattern using pedigree charts for all patients were obtained. Patients with a shallow anterior chamber, high IOP, or glaucomatous optic discs were referred to the glaucoma department where they underwent additional IOP measurements, a gonioscopy, and disc evaluation by a glaucoma specialist. The prevalence of PACD was determined. Results: A total of 618 RP patients were examined during the study period, of which 95.1% had typical RP. The prevalence of primary angle-closure suspects was 2.9%, primary angle closure was 0.65%, and primary angle-closure glaucoma (PACG) was 2.27%. In contrast, the prevalence of primary open-angle glaucoma was 1.29%. The prevalence of PACG in those older than 40 years was 3.8% (95% confidence interval: 1.6-6.0). Conclusion: The prevalence of PACG in RP patients over 40 years was higher than that found in the general population of a similar age (3.8% vs. 0.8%). In our cohort of RP patients, 5.9% had PACD. Hence, gonioscopy is warranted in all RP patients to identify this condition and treat it appropriately.