Early manifestation of depressive‐like behavior in transgenic mice that express dementia with Lewy body‐linked mutant β‐synuclein
Aim We previously generated transgenic (Tg) mice that expressed P123H β‐synuclein (βS), a dementia with Lewy body‐linked mutant βS. Notably, these mice recapitulated neurodegenerative features of Lewy body disease, reflected by motor dysfunction, greater protein aggregation, and memory impairment. S...
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Published in | Neuropsychopharmacology reports Vol. 38; no. 2; pp. 95 - 97 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
John Wiley & Sons, Inc
01.06.2018
John Wiley and Sons Inc Wiley |
Subjects | |
Online Access | Get full text |
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Summary: | Aim
We previously generated transgenic (Tg) mice that expressed P123H β‐synuclein (βS), a dementia with Lewy body‐linked mutant βS. Notably, these mice recapitulated neurodegenerative features of Lewy body disease, reflected by motor dysfunction, greater protein aggregation, and memory impairment. Since recent studies suggested that non‐motor symptoms, such as depression, might be manifested in the prodromal stage of Lewy body disease, the main objective of the present study was to investigate the early expression of behavior in P123H βS Tg mice.
Methods
Nest building, locomotor activity, and depressive‐like behavior were assessed using 6‐ to 10‐month‐old male and female P123H βS Tg and wildtype mice.
Key Results
P123H βS Tg mice exhibited hyperlocomotor activity in a novel environment, a decrease in mobility time in the tail suspension test, and impairments in nest building.
Conclusions
Importantly, these non‐motor behaviors were manifested before the onset of motor dysfunction, suggesting that P123H βS Tg mice could be a valid model for investigating the early phase of Lewy body disease.
Transgenicmice that expressed P123H beta‐synuclein recapitulated neurodegenerative features of Lewy body disease. In the present study, we found that P123H beta‐synuclein transfenic mice exhibited non‐motor behaviors including depressive‐like behavior that were manifested before the onset of motor dysfunction. Thus, P123H beta‐synuclein transgenic mice may be a valid model for investigatig early hase of Lewy body disease. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 2574-173X 2574-173X |
DOI: | 10.1002/npr2.12009 |