Resting energy expenditure and food-induced thermogenesis in obese children

• Published in: Journal of pediatric gastroenterology and nutrition Vol. 16; no. 4; pp. 451 - 457
• Main Authors: Tounian, P. (Armand-Trousseau Teaching Hospital, Paris, France), Girardet, J.P, Carlier, L, Frelut, M.L, Veinberg, F, Fontaine, J.L
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott-Raven Publishers 01.05.1993; Lippincott
• Subjects: Administration, Oral; Adolescent; Biological and medical sciences; Body Height; Body Mass Index; Body Temperature Regulation; Body Weight; Calorimetry, Indirect; Carbon Dioxide - metabolism; Child; Eating - physiology; ENERGIA; ENERGIE; Energy Intake; Energy Metabolism; ENFANT; Female; Humans; INGESTION DE ALIMENTOS; Medical sciences; Metabolic diseases; METABOLISME ENERGETIQUE; METABOLISMO ENERGETICO; NINOS; Obesity; Obesity - metabolism; Oxygen Consumption; PRISE ALIMENTAIRE; Regression Analysis; Rest - physiology; SOBREPESO; Sucrose - administration & dosage; SURPOIDS; TERMORREGULACION; THERMOREGULATION; Human; Obesity; Energy metabolism; Pathogenesis; Risk factor; Metabolic diseases; Calorimetry; Exploration; Child
• ISSN: 0277-2116; 1536-4801
• DOI: 10.1097/00005176-199305000-00019

Nineteen overweight girls 14.54 +/- 0.38 years of age were studied. Results were compared with those obtained in eight age-matched (14.07 +/- 0.51 years) and sex-matched normal weight controls. Energy expenditure (EE) was determined using open-circuit indirect calorimetry at rest, both after a 12-h fast and after an oral sucrose load of 3 g/kg ideal body weight. Food-induced thermogenesis (FIT) was evaluated by computing the area under the curve of the EE response above resting energy expenditure (REE) during the first 3 h after the sucrose load, REE (kcal/day) was higher in the overweight patients (1,818 +/- 46 vs. 1,527 +/- 67; p = 0.002); REE standardized by fat-free mass (FFM) (kcal/kg FFM/day) was lower in obese children than in controls (35.2 +/- 1.0 vs. 44.9 +/- 1.9; p = 0.0001). A linear correlation between REE and FFM was evidenced in both controls and overweight subjects (r = 0.78 and 0.68, respectively; p = 0.05 and p 0.001, respectively). Actual REE in the obese children was significantly lower than the value predicted by applying the regression equation of REE on FFM in controls to the actual FFM in obese children (paired t test; p