Bacterial inhibition of inflammatory responses via TLR‐independent mechanisms

Summary Identification of cellular processes modulated by microbial organisms that undermine and disarm mammalian host defences against bacterial invaders has been the focus of significant biomedical research. In this microreview we will illustrate the role of bacterial N‐acyl homoserine lactones (A...

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Bibliographic Details
Published inCellular microbiology Vol. 15; no. 4; pp. 527 - 536
Main Authors Kravchenko, Vladimir V., Kaufmann, Gunnar F.
Format Journal Article
LanguageEnglish
Published England Hindawi Limited 01.04.2013
Subjects
Acyl-Butyrolactones - metabolism
Bacteria
Bacteria - immunology
Bacteria - metabolism
Cancer
Host-Pathogen Interactions - drug effects
Humans
Immune Evasion
Immunity, Innate - drug effects
Inflammation
Medical research
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Summary:Summary Identification of cellular processes modulated by microbial organisms that undermine and disarm mammalian host defences against bacterial invaders has been the focus of significant biomedical research. In this microreview we will illustrate the role of bacterial N‐acyl homoserine lactones (AHL) as a strategy utilized by Gram‐negative bacterial pathogens to enable colonization of the host through AHL‐mediated inhibition of inflammation induced via innate immune receptor mechanisms. We will also highlight some of the signalling pathways in which the study of AHL‐mediated effects on mammalian cells might lead to the discovery of global underlying principles linking inflammation and immunity to many chronic human diseases, including cancer and obesity.
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ISSN:1462-5814
1462-5822
DOI:10.1111/cmi.12109