NK gene complex haplotype variability and host resistance alleles to murine cytomegalovirus in wild mouse populations
The NK gene complex (NKC) on mouse chromosome 6 encodes receptors that are expressed on NK cells, such as Ly49H, and is involved in regulating NK cell control of virus infections, such as murine cytomegalovirus (MCMV). In the present study, we investigated the level of allelic heterogeneity in NKC l...
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Published in | Immunology and cell biology Vol. 83; no. 2; pp. 144 - 149 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Nature Publishing Group
01.04.2005
Blackwell Science Ltd |
Subjects | |
Online Access | Get full text |
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Summary: | The NK gene complex (NKC) on mouse chromosome 6 encodes receptors that are expressed on NK cells, such as Ly49H, and is involved in regulating NK cell control of virus infections, such as murine cytomegalovirus (MCMV). In the present study, we investigated the level of allelic heterogeneity in NKC loci in populations of outbred wild mice. This work revealed extensive levels of heterogeneity within two wild mouse populations. Analysis of MCMV replication in a population of specific pathogen‐free outbred wild mice revealed that low viral titres, which are normally associated with the Cmv1 r allele of the Cmv1 host resistance locus, were not prevalent in the mice tested. Hence, NKC‐mediated resistance associated with Cmv1 r/Ly49H‐like effects was rare in this population. Overall, these data indicate that the NKC region is highly polymorphic and thus it is very likely that it confers on mice sufficient variability to cope with infection by a range of pathogens. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0818-9641 1440-1711 |
DOI: | 10.1111/j.1440-1711.2005.01311.x |