Antioxidant and neurosedative properties of polyphenols and iridoids from Lippia alba

• Published in: Phytotherapy research Vol. 22; no. 2; pp. 256 - 258
• Main Authors: Hennebelle, Thierry, Sahpaz, Sevser, Gressier, Bernard, Joseph, Henry, Bailleul, François
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.02.2008; Wiley
• Subjects: antioxidant; Antioxidants - chemistry; Antioxidants - isolation & purification; Antioxidants - pharmacology; Binding, Competitive - drug effects; Biological and medical sciences; Biphenyl Compounds - chemistry; Female; flavonoid; Flavonoids - chemistry; Flavonoids - isolation & purification; Flavonoids - pharmacology; Free Radical Scavengers - chemistry; Free Radical Scavengers - isolation & purification; Free Radical Scavengers - pharmacology; General pharmacology; Humans; Hydrazines - chemistry; Hypnotics and Sedatives - chemistry; Hypnotics and Sedatives - isolation & purification; Hypnotics and Sedatives - pharmacology; iridoid; Iridoids - chemistry; Iridoids - isolation & purification; Iridoids - pharmacology; Lippia - chemistry; Lippia alba; Male; Medical sciences; Molecular Structure; Neutrophils - cytology; Neutrophils - drug effects; Neutrophils - metabolism; Oxidation-Reduction - drug effects; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phenols - chemistry; Phenols - isolation & purification; Phenols - pharmacology; phenylpropanoid; Picrates; Plant Extracts - chemistry; Plant Extracts - pharmacology; Polyphenols; Reactive Oxygen Species - metabolism; Receptors, GABA-A - metabolism; sedative; Iridoid; phenylpropanoid; Terpenoid; Pharmacognosy; Lippia alba; Antioxidant; Flavonoid; Medicinal plant; Polyphenol; Verbenaceae; Dicotyledones; Angiospermae; Plant origin; Phenols; Monoterpene; Spermatophyta; Sedative
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/ptr.2266

The neurosedative and antioxidative properties of some major compounds isolated from a citral chemotype of Lippia alba were investigated. Binding assays were performed on two CNS inhibitory targets: benzodiazepine and GABAA receptors. The most active compound was luteolin‐7‐diglucuronide, with half maximal inhibitory concentrations (IC50) of 101 and 40 µm, respectively. Fifteen compounds isolated from Lippia alba were tested for their radical scavenging capacities against DPPH. Four of the major compounds (verbascoside, calceolarioside E, luteolin‐7‐diglucuronide and theveside) were also tested for their antioxidant activity against superoxide radical‐anion in cell‐free (hypoxanthine‐xanthine oxidase) and cellular (PMA‐stimulated neutrophil granulocytes) systems. Copyright © 2007 John Wiley & Sons, Ltd.