Effect of chlorpromazine and clozapine on plasma concentrations of haloperidol in a patient with schizophrenia

A 40-year-old patient being treated for schizophrenia developed elevated plasma levels of haloperidol (HAL) in combination with chlorpromazine (CPZ) and during overlap treatment with clozapine. Competitive inhibition of HAL by first CPZ and then clozapine is discussed as a possible mechanism.

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Bibliographic Details
Published inJournal of clinical pharmacology Vol. 40; no. 11; p. 1296
Main Author Allen, S A
Format Journal Article
LanguageEnglish
Published England 01.11.2000
Subjects
Adult
Antipsychotic Agents - pharmacology
Chlorpromazine - pharmacology
Clozapine - pharmacology
Drug Interactions
Drug Therapy, Combination
Haloperidol - blood
Humans
Male
Schizophrenia - drug therapy
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Summary:A 40-year-old patient being treated for schizophrenia developed elevated plasma levels of haloperidol (HAL) in combination with chlorpromazine (CPZ) and during overlap treatment with clozapine. Competitive inhibition of HAL by first CPZ and then clozapine is discussed as a possible mechanism.
ISSN:0091-2700
DOI:10.1177/009127000004001115