Effect of chlorpromazine and clozapine on plasma concentrations of haloperidol in a patient with schizophrenia
A 40-year-old patient being treated for schizophrenia developed elevated plasma levels of haloperidol (HAL) in combination with chlorpromazine (CPZ) and during overlap treatment with clozapine. Competitive inhibition of HAL by first CPZ and then clozapine is discussed as a possible mechanism.
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Published in | Journal of clinical pharmacology Vol. 40; no. 11; p. 1296 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
England
01.11.2000
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Subjects | |
Online Access | Get more information |
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Summary: | A 40-year-old patient being treated for schizophrenia developed elevated plasma levels of haloperidol (HAL) in combination with chlorpromazine (CPZ) and during overlap treatment with clozapine. Competitive inhibition of HAL by first CPZ and then clozapine is discussed as a possible mechanism. |
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ISSN: | 0091-2700 |
DOI: | 10.1177/009127000004001115 |