Mass‐spectrometry analysis of the human pineal proteome during night and day and in autism

The human pineal gland regulates day‐night dynamics of multiple physiological processes, especially through the secretion of melatonin. Using mass‐spectrometry‐based proteomics and dedicated analysis tools, we identify proteins in the human pineal gland and analyze systematically their variation thr...

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Published inJournal of pineal research Vol. 70; no. 3; pp. e12713 - n/a
Main Authors Dumas, Guillaume, Goubran‐Botros, Hany, Matondo, Mariette, Pagan, Cécile, Boulègue, Cyril, Chaze, Thibault, Chamot‐Rooke, Julia, Maronde, Erik, Bourgeron, Thomas
Format Journal Article
LanguageEnglish
Published England Wiley 01.04.2021
John Wiley and Sons Inc
Subjects
antioxidant
autism spectrum disorders
Biochemistry, Molecular Biology
Cellular Biology
chaperon proteins
circadian rhythm
energy production
Life Sciences
mass spectrometry
Original
pineal gland
antioxidant
chaperon proteins
circadian rhythm
energy production
mass spectrometry
autism spectrum disorders
pineal gland
autism spectrum disorder
mass spectometry
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Summary:The human pineal gland regulates day‐night dynamics of multiple physiological processes, especially through the secretion of melatonin. Using mass‐spectrometry‐based proteomics and dedicated analysis tools, we identify proteins in the human pineal gland and analyze systematically their variation throughout the day and compare these changes in the pineal proteome between control specimens and donors diagnosed with autism. Results reveal diverse regulated clusters of proteins with, among others, catabolic carbohydrate process and cytoplasmic membrane‐bounded vesicle‐related proteins differing between day and night and/or control versus autism pineal glands. These data show novel and unexpected processes happening in the human pineal gland during the day/night rhythm as well as specific differences between autism donor pineal glands and those from controls.
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Maronde and Bourgeron contributed equally to this study.
Dumas, Goubran‐Botros and Matondo contributed equally to this study.
ISSN:0742-3098
1600-079X
DOI:10.1111/jpi.12713