Reinnervation after nerve suture in rat groin flaps

• Published in: Microsurgery Vol. 18; no. 1; pp. 1 - 5
• Main Authors: Ranne, Juha O., Lähteenmäki, P. Tapani, Vaalasti, Annikki, Waris, Timo H., Lindholm, T. Sam
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 1998; Wiley-Liss
• Subjects: Anastomosis, Surgical; Animals; Biological and medical sciences; Biomarkers; Calcitonin Gene-Related Peptide; Cranial nerves. Peripheral nerves. Autonomic nervous system; Groin; Medical sciences; Microsurgery; Nerve Regeneration; Neurosurgery; Rats; Rats, Wistar; Skin - innervation; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgical Flaps - innervation; Immunohistochemistry; Peripheral nerve; Rat; Rodentia; Surgical anastomosis; Biological marker; Inguinal; Suturation; Experimental study; Result; Pathology; Microcirculation; Regeneration; Vertebrata; Mammalia; Treatment; Surgery; Animal; Skin; Reinnervation; Technique; Flap (surgery); Bibliographic review
• ISSN: 0738-1085; 1098-2752
• DOI: 10.1002/(SICI)1098-2752(1998)18:1<1::AID-MICR1>3.0.CO;2-R

Regeneration of sensory and adrenergic nerves in the skin was studied in rats. The aim was to investigate the effect of reanastomosing the cut nerve ends of the nerve trunk leading to the microvascular groin flap. Reinnervation was demonstrated immunohistochemically using calcitonin gene‐related peptide (CGRP) as marker for sensory nerves, neuropeptide Y (NPY) and tyrosine hydroxylase (TH) as markers for adrenergic nerves and Protein Gene Product 9.5 (PGP 9.5) as general neuronal marker. It was demonstrated that reanastomosing of the nerve trunk was favourable for both the sensory and sympathetic reinnervation of microsurgical flaps. © 1998 Wiley‐Liss, Inc. MICROSURGERY 18:1–5, 1998.