Case report: A case of light chain deposition disease involving liver and stomach with chronic hepatitis C virus infection and hepatocellular carcinoma

• Published in: Journal of medical virology Vol. 83; no. 5; pp. 810 - 814
• Main Authors: Kwon, Jung Hee, Jeong, Sook-Hyang, Kim, Jin-Wook, Bang, Soo-Mee, Kim, Haeryoung, Kim, Young Hoon, Song, Sang Hoon
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.05.2011; Wiley; Wiley Subscription Services, Inc
• Subjects: Antibodies, Monoclonal - metabolism; B cell proliferation; Biological and medical sciences; Bone Marrow; Carcinoma, Hepatocellular - complications; Carcinoma, Hepatocellular - diagnosis; Carcinoma, Hepatocellular - pathology; Fundamental and applied biological sciences. Psychology; HCC; HCV; Hepatitis C virus; Hepatitis C, Chronic - complications; Hepatitis C, Chronic - diagnosis; Hepatitis C, Chronic - pathology; Histocytochemistry; Human viral diseases; Humans; Immunohistochemistry; Infectious diseases; light chain deposition disease; Liver - pathology; Liver Neoplasms - complications; Liver Neoplasms - diagnosis; Liver Neoplasms - pathology; Magnetic Resonance Imaging; Male; Medical sciences; Microbiology; Microscopy; Middle Aged; Miscellaneous; Radiography, Abdominal; Stomach - pathology; Viral diseases; Virology; Cell proliferation; Stomach; light chain deposition disease; Digestive system; Hepatocellular carcinoma; Hepatic disease; HCC; B-Lymphocyte; Malignant tumor; Light peptide chain; Infection; Virus; Case study; Viral disease; Digestive diseases; HCV; Flaviviridae; Hepatitis C virus; B cell proliferation; Hepacivirus; Cancer; Viral hepatitis C
• ISSN: 0146-6615; 1096-9071
• DOI: 10.1002/jmv.22050

Light chain deposition disease (LCDD) is a rare, plasma cell proliferative disorder characterized by mainly abnormal light chain deposition in various organs. Hepatitis C virus (HCV) is a hepatotrophic and lymphotrophic virus and significantly related to B‐cell proliferation. This is a case report of systemic LCDD involving liver, stomach, bone marrow, and probably kidney, in a patient with HCV‐related hepatocellular carcinoma (HCC). A 62‐year‐old man with chronic HCV infection who presented with a small HCC in segment 8 of the liver and nephrotic syndrome showed kappa typed immunoglobulin light chain depositions in biopsy specimens of bone marrow, stomach, and non‐tumorous liver parenchyma. After treatment of the HCC with transarterial chemoembolization, antiviral therapy for chronic hepatitis C was started. The patient showed early virologic response at 12 weeks of treatment; however, antiviral therapy was discontinued due to adverse effects and he was lost to follow‐up. This is the first case of LCDD involving the liver and stomach in a patient with chronic HCV infection and HCC, which may represent LCDD as a rare HCV‐associated B cell proliferative disease. J. Med. Virol. 83:810–814, 2011. © 2011 Wiley‐Liss, Inc.