Topiramate for Phantom Limb Pain: A Time-Series Analysis

ABSTRACT There is growing evidence of topiramate's efficacy in treating neuropathic pain. This article reports a detailed analysis of the response of four amputee subjects with phantom limb pain. Individual time‐series analyses revealed that three out of four amputee participants receiving topi...

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Published inPain medicine (Malden, Mass.) Vol. 6; no. 5; pp. 375 - 378
Main Authors Harden, R. Norman, Houle, Tim T., Remble, Thomas A., Lin, Wendy, Wang, Kenten, Saltz, Samuel
Format Journal Article
LanguageEnglish
Published Oxford, UK and Malden, USA Blackwell Science Inc 01.09.2005
Subjects
Adult
Aged
Anticonvulsants - adverse effects
Anticonvulsants - therapeutic use
Antiepileptics
Fructose - administration & dosage
Fructose - analogs & derivatives
Fructose - therapeutic use
Humans
Male
Middle Aged
Neuralgia - drug therapy
Neuralgia - psychology
Pain Measurement
Phantom Limb - drug therapy
Phantom Limb - psychology
Phantom Pain
Pilot Projects
Time Factors
Time-Series Analysis
Topiramate
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Summary:ABSTRACT There is growing evidence of topiramate's efficacy in treating neuropathic pain. This article reports a detailed analysis of the response of four amputee subjects with phantom limb pain. Individual time‐series analyses revealed that three out of four amputee participants receiving topiramate had statistically significant decreases in pain, with the peak effect noted at 800 mg daily. This analysis supports a hypothesis that topiramate may be effective in reducing phantom limb pain, and suggests a definitive study is indicated.
Bibliography:ArticleID:PME60
istex:8A9175C08160B82D3E579E2B72375515BA3FBEF6
ark:/67375/WNG-10W13ZBC-T
This work is the amputee subset of an investigator‐initiated screening trial partially funded by an unrestricted grant from Ortho McNeil laboratories.
ISSN:1526-2375
1526-4637
DOI:10.1111/j.1526-4637.2005.00060.x