Glioblastoma-Specific Strategies of Vascularization: Implications in Anti-Angiogenic Therapy Resistance

Angiogenesis has long been implicated as a crucial process in GBM growth and progression. GBM can adopt several strategies to build up its abundant and aberrant vasculature. Targeting GBM angiogenesis has gained more and more attention in anti-cancer therapy, and many strategies have been developed...

Full description

Saved in:
Bibliographic Details
Published inJournal of personalized medicine Vol. 12; no. 10; p. 1625
Main Authors Buccarelli, Mariachiara, Castellani, Giorgia, Ricci-Vitiani, Lucia
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.10.2022
MDPI
Subjects
Angiogenesis
anti-angiogenic therapy resistance
Brain cancer
Cancer therapies
Cell division
Drug resistance
Genotype & phenotype
Glioblastoma
glioblastoma stem-like cells
Hypoxia
Morphology
Mortality
Precision medicine
Review
Tumors
Vascular endothelial growth factor
Vascularization
Online AccessGet full text

Cover

More Information
Summary:Angiogenesis has long been implicated as a crucial process in GBM growth and progression. GBM can adopt several strategies to build up its abundant and aberrant vasculature. Targeting GBM angiogenesis has gained more and more attention in anti-cancer therapy, and many strategies have been developed to interfere with this hallmark. However, recent findings reveal that the effects of anti-angiogenic treatments are temporally limited and that tumors become refractory to therapy and more aggressive. In this review, we summarize the GBM-associated neovascularization processes and their implication in drug resistance mechanisms underlying the transient efficacy of current anti-angiogenic therapies. Moreover, we describe potential strategies and perspectives to overcome the mechanisms adopted by GBM to develop resistance to anti-angiogenic therapy as new potential therapeutic approaches.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
These authors contributed equally to this work.
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm12101625