Squamous intraepithelial neoplasia in an ovarian cyst, cervical intraepithelial neoplasia, and human papillomavirus

• Published in: Human pathology Vol. 26; no. 3; pp. 344 - 347
• Main Authors: Sworn, M.J, Jones, H, Letchworth, A.T, Herrington, C.S, McGee, J.O'D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.03.1995; Elsevier
• Subjects: Adult; Biological and medical sciences; cervical intraepithelial neoplasia; Cervical Intraepithelial Neoplasia - complications; Cervical Intraepithelial Neoplasia - pathology; Cervical Intraepithelial Neoplasia - secondary; Female; Female genital diseases; Gynecology. Andrology. Obstetrics; human papillomavirus; Humans; In Situ Hybridization; Medical sciences; nonisotopic in situ hybridization; Ovarian Cysts - complications; Ovarian Cysts - pathology; Ovarian Neoplasms - pathology; Ovarian Neoplasms - secondary; Papillomaviridae; Papillomavirus Infections - complications; Papillomavirus Infections - diagnosis; Polymerase Chain Reaction; squamous intraepithelial neoplasia in an ovarian cyst; Tumor Virus Infections - complications; Tumor Virus Infections - diagnosis; Tumors; Uterine Cervical Neoplasms - complications; Uterine Cervical Neoplasms - pathology; PBS; nonisotopic in situ hybridization; NISH; human papillomavirus; CIN; squamous intraepithelial neoplasia in an ovarian cyst; HE; cervical intraepithelial neoplasia; polymerase chain reaction; PCR; HPV; Human; Dysplasia; Squamous cell carcinoma; Carcinoma in situ; In situ; Papovaviridae; Malignant tumor; Uterine cervix; Hybridization; Female genital diseases; Papillomavirus; Virus; Case study; Polymerase chain reaction; Ovarian diseases; Ovary; Concomitant disease; Human papillomavirus; Cyst; Molecular biology; Uterine cervix diseases
• ISSN: 0046-8177; 1532-8392
• DOI: 10.1016/0046-8177(95)90069-1

A case of squamous intraepithelial neoplasia in an ovarian cyst in association with cervical intraepithelial neoplasia (CIN) III is described. In view of the association of human papillomavirus (HPV) and CIN, the possibility that HPV infection could be associated with similar changes in the ovary was postulated. The HPV genome was shown in formalin-fixed tissue of the cervical lesion by nonisotopic in situ hybridization (NISH) and by the polymerase chain reaction (PCR). However, HPV could not be shown in the ovarian lesion by NISH or PCR. On the basis of these findings there appears to be no association between HPV infection and squamous intraepithelial neoplasia in an ovarian cyst.