Ankle Osteoarthritis Aetiology

Ankle osteoarthritis affects 1% of the population and, unlike gonarthrosis or coxarthrosis, is secondary to previous trauma in more than 75% of cases. Another peculiarity of this disease is that it affects a younger and active population, with socio-occupational implications. Mechanical factors, suc...

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Bibliographic Details
Published inJournal of clinical medicine Vol. 10; no. 19; p. 4489
Main Authors Herrera-Pérez, Mario, González-Martín, David, Vallejo-Márquez, Mercedes, Godoy-Santos, Alexandre L., Valderrabano, Victor, Tejero, Sergio
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 29.09.2021
MDPI
Subjects
Ankle
ankle cartilage
ankle fractures
ankle osteoarthritis
Apoptosis
Arthritis
Cartilage
Chronic illnesses
Clinical medicine
Etiology
Extracellular matrix
Injuries
Ligaments
Osteoarthritis
Review
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Summary:Ankle osteoarthritis affects 1% of the population and, unlike gonarthrosis or coxarthrosis, is secondary to previous trauma in more than 75% of cases. Another peculiarity of this disease is that it affects a younger and active population, with socio-occupational implications. Mechanical factors, such as incongruity, instability, malalignment, and impacts, which increase stress on isolated areas of the ankle cartilage, have been clearly associated with the development of osteoarthritis. However, we cannot ignore the importance of pro-inflammatory mediators present from the moment of fracture as triggers of the cascade that eventually causes chondrocyte cell death, ultimately responsible for ankle osteoarthritis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm10194489