Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey

1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) was administered via the intraperitoneal route to squirrel monkeys. Akinesia, rigidity and hypophonia were seen after repeated doses of 2 mg/kg. Postural tremor was present in one animal. Neuropathologic examination revealed cell loss restricted to...

Full description

Saved in:
Bibliographic Details
Published inBrain research Vol. 292; no. 2; p. 390
Main Authors Langston, J W, Forno, L S, Rebert, C S, Irwin, I
Format Journal Article
LanguageEnglish
Published Netherlands 06.02.1984
Subjects
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Animals
Antiparkinson Agents - therapeutic use
Brain Diseases - chemically induced
Brain Diseases - drug therapy
Brain Diseases - pathology
Disease Models, Animal
Microscopy, Electron
Parkinson Disease
Pyridines - toxicity
Saimiri
Substantia Nigra - ultrastructure
Online AccessGet more information

Cover

More Information
Summary:1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) was administered via the intraperitoneal route to squirrel monkeys. Akinesia, rigidity and hypophonia were seen after repeated doses of 2 mg/kg. Postural tremor was present in one animal. Neuropathologic examination revealed cell loss restricted to the zona compacta of the substantia nigra. MPTP appears effective in producing an animal model for Parkinson's disease in the squirrel monkey, and may be one of the more selective neurotoxins described to date.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(84)90777-7