Ductal Adenocarcinoma of the Prostate with Novel Genetic Alterations Characterized by Next-Generation Sequencing

Ductal adenocarcinoma of the prostate (DAP) is an uncommon variant of prostate cancer associated with aggressive disease and poor outcome. It presents most frequently as a mixed tumor combined with acinar adenocarcinoma. Although the histopathological features of DAP are well known, its genomic char...

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Bibliographic Details
Published inCurrent oncology (Toronto) Vol. 31; no. 3; pp. 1556 - 1561
Main Authors Zara Rozalen, Alexandra, Martin, Jose Manuel, Rajendran, Rithika, Jain, Maneesh, Nava, Victor E
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.03.2024
MDPI
Subjects
Adenocarcinoma
Carcinoma, Acinar Cell - genetics
Carcinoma, Acinar Cell - pathology
Carcinoma, Ductal - genetics
Carcinoma, Ductal - pathology
Case Report
ductal adenocarcinoma
genetic mutations
High-Throughput Nucleotide Sequencing
Humans
Male
next-generation sequencing
Prostate - pathology
Prostate cancer
Prostatic Neoplasms - therapy
ductal adenocarcinoma
genetic mutations
prostate cancer
next-generation sequencing
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Summary:Ductal adenocarcinoma of the prostate (DAP) is an uncommon variant of prostate cancer associated with aggressive disease and poor outcome. It presents most frequently as a mixed tumor combined with acinar adenocarcinoma. Although the histopathological features of DAP are well known, its genomic characteristics are still evolving, prompting the suggestion that all DAP would benefit from molecular analysis with the purpose of improving tumor recognition, genetic classification, and, ultimately, personalized therapy. Herein, we report a case of DAP with novel genetic alterations (BCOR P1153S, ERG M219I, KDR A750E, POLE S1896P, and RAD21 T461del).
ISSN:1718-7729
1198-0052
1718-7729
DOI:10.3390/curroncol31030118