Genetic and Immunological Pathogenesis of Atopic Dermatitis

• Published in: Journal of investigative dermatology Vol. 144; no. 5; pp. 954 - 968
• Main Authors: Schuler, Charles F., Tsoi, Lam C., Billi, Allison C., Harms, Paul W., Weidinger, Stephan, Gudjonsson, Johann E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2024
• Subjects: Animals; Atopic dermatitis; Dermatitis, Atopic - genetics; Dermatitis, Atopic - immunology; Dermatitis, Atopic - physiopathology; Epidermal barrier; Epithelial barrier; Filaggrin Proteins - genetics; Gene-Environment Interaction; Genetic Predisposition to Disease; Genetics; GWAS; Humans; Intermediate Filament Proteins - genetics; IL-6R; FDA; GWAS; AD; MR; PRS; STAT; Th; Atopic dermatitis; Epithelial barrier; Epidermal barrier; Genetics; TLR

Type 2 immune–mediated diseases give a clear answer to the issue of nature (genetics) versus nurture (environment). Both genetics and environment play vital complementary roles in the development of atopic dermatitis (AD). As a key component of the atopic march, AD demonstrates the interactive natur...