Genetic and Immunological Pathogenesis of Atopic Dermatitis

Type 2 immune–mediated diseases give a clear answer to the issue of nature (genetics) versus nurture (environment). Both genetics and environment play vital complementary roles in the development of atopic dermatitis (AD). As a key component of the atopic march, AD demonstrates the interactive natur...

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Bibliographic Details
Published inJournal of investigative dermatology Vol. 144; no. 5; pp. 954 - 968
Main Authors Schuler, Charles F., Tsoi, Lam C., Billi, Allison C., Harms, Paul W., Weidinger, Stephan, Gudjonsson, Johann E.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.05.2024
Subjects
Animals
Atopic dermatitis
Dermatitis, Atopic - genetics
Dermatitis, Atopic - immunology
Dermatitis, Atopic - physiopathology
Epidermal barrier
Epithelial barrier
Filaggrin Proteins - genetics
Gene-Environment Interaction
Genetic Predisposition to Disease
Genetics
GWAS
Humans
Intermediate Filament Proteins - genetics
IL-6R
FDA
GWAS
AD
MR
PRS
STAT
Th
Atopic dermatitis
Epithelial barrier
Epidermal barrier
Genetics
TLR
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Summary:Type 2 immune–mediated diseases give a clear answer to the issue of nature (genetics) versus nurture (environment). Both genetics and environment play vital complementary roles in the development of atopic dermatitis (AD). As a key component of the atopic march, AD demonstrates the interactive nature of genetic and environmental contributions to atopy. From sequence variants in the epithelial barrier gene encoding FLG to the hygiene hypothesis, AD combines a broad array of contributions into a single syndrome. This review will focus on the genetic contribution to AD and where genetics facilitates the elicitation or enhancement of AD pathogenesis.
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AUTHOR CONTRIBUTIONS
Conceptualization: CFS, JG; Methodology: CFS, LCT, ACB, PWH, SW, JEG; Supervision: JEG; Visualization: CFS, PWH, JEG; Writing – Original Draft Preparation: CFS, LCT, ACB, JEG; Writing – Review and Editing: CFS, LCT, ACB, PWH, SW, JEG
ISSN:0022-202X
1523-1747
1523-1747
DOI:10.1016/j.jid.2023.10.019