In situ stem cell therapy: novel targets, familiar challenges

Tissue engineering approaches for expanding, differentiating and engrafting embryonic or adult stem cells have significant potential for tissue repair but harnessing endogenous stem cell populations offers numerous advantages over these approaches. There has been rapid basic biological progress in t...

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Bibliographic Details
Published inTrends in biotechnology (Regular ed.) Vol. 23; no. 2; pp. 78 - 83
Main Authors Agrawal, Smita, Schaffer, David V.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.02.2005
Elsevier Science
Elsevier Limited
Subjects
Amyotrophic lateral sclerosis
Biological and medical sciences
Biotechnology
Blood-brain barrier
Brain research
Cell Differentiation
Central nervous system
Central Nervous System - cytology
Disease
Engineering research
Fundamental and applied biological sciences. Psychology
Gene expression
Genetic engineering
Genetic Therapy - methods
Health. Pharmaceutical industry
Heredodegenerative Disorders, Nervous System - pathology
Heredodegenerative Disorders, Nervous System - therapy
Humans
Industrial applications and implications. Economical aspects
Miscellaneous
Neurogenesis
Proteins
Proteins - administration & dosage
Proteins - pharmacology
Spinal cord
Stem cells
Stem Cells - drug effects
Stem Cells - pathology
Studies
Tissue engineering
Regeneration
Cell therapy
Stem cell
In situ
Central nervous system
Review
Gene therapy
Protein
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Summary:Tissue engineering approaches for expanding, differentiating and engrafting embryonic or adult stem cells have significant potential for tissue repair but harnessing endogenous stem cell populations offers numerous advantages over these approaches. There has been rapid basic biological progress in the identification of stem cell niches throughout the body and the molecular factors that regulate their function. These niches represent novel therapeutic targets and efforts to use them involve the familiar challenges of delivering molecular medicines in vivo. Here we review recent progress in the use of genes, proteins and small molecules for in situ stem cell control and manipulation, with a focus on using stem cells of the central nervous system for neuroregeneration.
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ISSN:0167-7799
1879-3096
DOI:10.1016/j.tibtech.2004.12.004