Increase of erythrocyte resistance to hemolysis and modification of membrane lipids induced by hemodialysis

Mechanical fragility, deformability and lipid composition of erythrocyte membranes were studied in 22 urémic dialysed patients before and after dialysis in comparison to controls. While deformability was not affected by a dialysis session, osmotic and saponin resistances to hemolysis were significan...

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Bibliographic Details
Published inClinica chimica acta Vol. 178; no. 3; pp. 271 - 282
Main Authors Peuchant, Evelyne, Salles, Christine, Vallot, Catherine, Wone, Christian, Jensen, Raymond
Format Journal Article
LanguageEnglish
Published Shannon Elsevier B.V 30.12.1988
Elsevier
Subjects
Adult
Aged
Biological and medical sciences
Cell membranes. Ionic channels. Membrane pores
Cell structures and functions
Erythrocyte
Erythrocyte Deformability
Erythrocyte Membrane - analysis
Erythrocytes - physiology
Female
Fundamental and applied biological sciences. Psychology
Hemodialysis
Hemolysis
Hemolytic resistance
Humans
Male
Membrane lipid
Membrane Lipids - analysis
Middle Aged
Molecular and cellular biology
Renal Dialysis
Uremia - blood
Uremia - therapy
Erythrocyte
Hemolytic resistance
Hemodialysis
Membrane lipid
Human
Hemolysis
Resistance
Deformability
Fluidity
Plasma membrane
Red blood cell
Lipids
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Summary:Mechanical fragility, deformability and lipid composition of erythrocyte membranes were studied in 22 urémic dialysed patients before and after dialysis in comparison to controls. While deformability was not affected by a dialysis session, osmotic and saponin resistances to hemolysis were significantly increased after dialysis ( p < 0.001). The lipid composition of erythrocyte membranes was also altered during dialysis, with a notable increase in cholesterol and a different phospholipid distribution, i.e. phosphatidylcholine and sphingomyelin significantly decreased ( p < 0.001). Likewise, the fatty acid distribution showed large variations with an increase in polyunsaturated fatty acid. The acute effect of dialysis on the membrane lipid composition seems to be linked to erythrocyte alterations. Its significance is discussed in relation to the asymmetric transverse distribution of phospholipids previously described in human erythrocyte.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-8981
1873-3492
DOI:10.1016/0009-8981(88)90235-5