Effects of Nelumbo nucifera Gaertn. Petal Tea Extract on Hepatotoxicity and Oxidative Stress Induced by Mancozeb in Rat Model

• Published in: Toxics (Basel) Vol. 11; no. 6; p. 480
• Main Authors: Nuchniyom, Pimchanok, Intui, Ketsarin, Laoung-On, Jiraporn, Jaikang, Churdsak, Quiggins, Ranida, Photichai, Kornravee, Sudwan, Paiwan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.05.2023; MDPI
• Subjects: 4-Hydroxynonenal; Antioxidants; Body weight; Body weight gain; Carboxymethyllysine; Drug dosages; Flavonoids; Fungicides; Glutathione; Health risks; Hepatotoxicity; Laboratory animals; Liver; Mancozeb; Nelumbo nucifera; NMR; Nuclear magnetic resonance; Olive oil; Oxidative stress; Pentosidine; Pesticides; Phytochemicals; Toxicity; Tyrosine; Veterinary medicine; Thailand; toxicity; liver; pesticides; glutathione; mancozeb; Nelumbo nucifera; oxidative stress
• ISSN: 2305-6304; 2305-6304
• DOI: 10.3390/toxics11060480

Mancozeb (Mz) is one of the most widely used pesticides that has been reported to cause adverse human health risks. White ( ) petals have therapeutic properties to prevent toxicity. Hence, this study attempted to determine the effects of extract on hepatotoxicity and oxidative stress in mancozeb-treated rats. Seventy-two male rats were divided into nine groups and designed with a control; extract was administered at the doses of 0.55, 1.1, and 2.2 mg/kg bw/day, Mz was administered at 500 mg/kg bw/day, and the co-treatment groups ( and Mz) were administered 0.55, 1.1, and 2.2 mg/kg bw/day of followed by administering Mz 500 mg/kg bw/day daily for 30 days. The results showed that all doses of extract did not induce hepatic toxicity and could suppress the toxicity of mancozeb by increasing body weight gain and decreasing relative liver weight, lobular inflammation, and total injury score. The combination treatment also decreased the molecular markers of oxidative stress (2-hydroxybutyric acid, 4-hydroxynonenal, l-tyrosine, pentosidine, and N6-carboxymethyllysine). Furthermore, the reduced glutathione and oxidized glutathione contents were adjusted close to the normal level. Therefore, extract is a natural antioxidant supplement that could decrease the toxicity of mancozeb and can be safely consumed.