Complete remission following pembrolizumab therapy for a patient with nephroureterectomy positive-margin carcinoma in situ and bladder cancer unresponsive to Bacille Calmette–Guérin therapy

An 82-year-old man was diagnosed with synchronous non-muscle-invasive bladder cancer and left lower ureteral carcinoma. He underwent transurethral resection of the bladder tumor, followed by total left nephroureterectomy after preoperative chemotherapy with four courses of gemcitabine and carboplati...

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Bibliographic Details
Published inSAGE open medical case reports Vol. 11; p. 2050313X231185444
Main Authors Nakamura, Ryohta, Hasegawa, Go, Ikeda, Yohei, Hara, Noboru, Nishiyama, Tsutomu
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.01.2023
Sage Publications Ltd
SAGE Publishing
Subjects
Bladder cancer
Case Report
pembrolizumab therapy
ureteral cancer
Bladder cancer
Bacille Calmette–Guérin intravesical infusion therapy-unresponsive
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Summary:An 82-year-old man was diagnosed with synchronous non-muscle-invasive bladder cancer and left lower ureteral carcinoma. He underwent transurethral resection of the bladder tumor, followed by total left nephroureterectomy after preoperative chemotherapy with four courses of gemcitabine and carboplatin. Histopathological findings showed positive-margin carcinoma in situ. In addition, since recurrence of non-muscle-invasive bladder cancer was observed in the bladder, Bacille Calmette–Guérin intravesical infusion therapy was performed, but the cancer persisted due to treatment resistance. After that, pembrolizumab therapy was performed, and complete remission was achieved.
ISSN:2050-313X
2050-313X
DOI:10.1177/2050313X231185444