Protection by acyl-carnitines and phenylmethylsulfonyl fluoride of rat heart subjected to ischemia and reperfusion

Perfusion of rat hearts according to the Langendorff technique with micromolar concentrations of palmitoylcarnitine or millimolar concentrations of phenylmethylsulfonyl fluoride protect the heart from deterioration by reperfusion after total-ischemia. This is based on the retention of the cytosolic...

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Published inBiochimica et biophysica acta Vol. 847; no. 1; pp. 62 - 66
Main Authors Hülsmann, W.C., Dubelaar, M.-L., Lamers, J.M.J., Maccari, F.
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 30.10.1985
Elsevier
North-Holland
Subjects
Animals
Biological and medical sciences
Ca 2+ overload
Calcium - metabolism
Carnitine - analogs & derivatives
Cell Membrane - physiology
Coronary Disease - drug therapy
Coronary Disease - enzymology
Coronary Disease - physiopathology
Cytosol - enzymology
Fundamental and applied biological sciences. Psychology
Glycogen Synthase - metabolism
Heart
Ischemia
L-Lactate Dehydrogenase - metabolism
Male
Membrane stabilization
Myocardial Contraction
Myoglobin - metabolism
Palmitoylcarnitine
Palmitoylcarnitine - therapeutic use
Perfusion
Phenylmethylsulfonyl fluoride
Phenylmethylsulfonyl Fluoride - therapeutic use
Phosphorylases - metabolism
Rat heart
Rats
Sulfones - therapeutic use
Vertebrates: cardiovascular system
Ischemia
PMSF
Ca 2+ overload
Phenylmethylsulfonyl fluoride
Membrane stabilization
Palmitoylcarnitine
Rat heart
Heart
Vertebrata
Oxygen
Mammalia
Reperfusion
Calcium
Rat
Overload
Rodentia
Inorganic element
Carnitine
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Summary:Perfusion of rat hearts according to the Langendorff technique with micromolar concentrations of palmitoylcarnitine or millimolar concentrations of phenylmethylsulfonyl fluoride protect the heart from deterioration by reperfusion after total-ischemia. This is based on the retention of the cytosolic enzymes determined (lactate dehydrogenase, glycogen phosphorylase and glycogen synthase) and of myoglobin, as well as on the resumption of contractile activity. Palmitoylcarnitine, like phenylmethylsulfonyl fluoride, could protect through plasmamembrane stabilization, since more hydrophylic compounds had no effect.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0167-4889
0006-3002
1879-2596
1878-2434
DOI:10.1016/0167-4889(85)90153-3