Probucol as an antioxidant and antiatherogenic drug

Recently, interest has increased in the hypothesis that low-density lipoprotein (LDL) modified by oxidation may lead to the initiation and to the development of atherosclerosis. In vitro studies of cellular interactions with LDL have revealed that various cells, including endothelial cells and smoot...

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Published inFree Radical Biology and Medicine Vol. 14; no. 1; pp. 67 - 77
Main Authors Kuzuya, Masafumi, Kuzuya, Fumio
Format Book Review Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 1993
Elsevier Science
Subjects
Animals
Antioxidant
Antioxidants - metabolism
Antioxidants - pharmacology
Arteriosclerosis - prevention & control
Atherosclerosis
Biological and medical sciences
Cardiovascular system
Cell Membrane - metabolism
Cholesterol - blood
Drug therapy
Free radicals
Free Radicals - metabolism
Humans
Lipoproteins, HDL - metabolism
Medical sciences
Miscellaneous
Oxidation-Reduction
Oxidized low-density lipoprotein
Pharmacology. Drug treatments
Probucol
Probucol - metabolism
Probucol - pharmacology
Probucol
Free radicals
Oxidized low-density lipoprotein
Antioxidant
Drug therapy
Atherosclerosis
Lipoprotein LDL
Chemotherapy
Review
Free radical
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Summary:Recently, interest has increased in the hypothesis that low-density lipoprotein (LDL) modified by oxidation may lead to the initiation and to the development of atherosclerosis. In vitro studies of cellular interactions with LDL have revealed that various cells, including endothelial cells and smooth muscles cells, can oxidize LDL. The biochemical changes in LDL may further enhance its atherogenic potential. In addition to these in vitro studies, there is in vivo evidence for oxidized LDL in atherosclerotic lesions and for circulating antibodies againts oxidized LDL. Probucol, 4,4′-(isopropylidenedithio) bis (2,6- di-tert-butylphenol), is a widely used cholesterol-lowering drug. Recently, there has been accumulating evidence for other mechanisms of probucol's antiatherogenic effects apart from cholesterol-lowering action. Attention has especially focused on probucol's antioxidant action in the mechanism of antiatherogenesis. In the present article, we will summarize the antiatherogenic and antioxidant actions of probucol.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:0891-5849
1873-4596
DOI:10.1016/0891-5849(93)90510-2