Biological studies of a new class of technetium complexes: the hexakis(alkylisonitrile)technetium(I) cations

This study describes the preparation and synthesis of a new class of cationic technetium compounds, the hexakis(alkylisonitrile)technetium(+1) complexes, at both carrier added and no carrier added concentrations in aqueous media from pertechnetate. Biological distribution and imaging data in animals...

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Published inInternational journal of nuclear medicine & biology Vol. 11; no. 3; pp. 225 - 234
Main Authors Jones, Alun G., Abrams, Michael J., Davison, Alan, Brodack, James W., Toothaker, Alan K., Adelstein, S.James, Kassis, Amin I.
Format Journal Article
LanguageEnglish
Published Tarrytown, NY Elsevier Inc 1984
Elsevier
Subjects
Animals
Biological and medical sciences
Cells, Cultured - metabolism
Cricetinae
Cricetulus
Dogs
Heart - diagnostic imaging
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Mice
Miscellaneous. Technology
Myocardial Infarction - diagnostic imaging
Nitriles - metabolism
Rabbits
Radioisotopes
Radionuclide investigations
Rats
Technetium - metabolism
Thallium
Tissue Distribution
Tomography, Emission-Computed
Radionuclide study
Nuclear medicine
Synthesis
Ligand
Scintigraphic agent
Preparation
Myocardium
Imagery
Technetium Compounds
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Summary:This study describes the preparation and synthesis of a new class of cationic technetium compounds, the hexakis(alkylisonitrile)technetium(+1) complexes, at both carrier added and no carrier added concentrations in aqueous media from pertechnetate. Biological distribution and imaging data in animals indicate that certain members of this class may be effective for cardiac imaging in man. The usefulness of these lipophilic water-soluble species for labeling mammalian cells is also reported.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0047-0740
DOI:10.1016/0047-0740(84)90004-4