Current Lack of Evidence for an Effect of Physical Activity Intervention Combined with Pharmacological Treatment on Bone Turnover Biomarkers in People with Osteopenia and Osteoporosis: A Systematic Review

The process of bone loss occurs silently and progressively with age, often appearing as osteopenia or osteoporosis or related fractures. Given the rapid raise in disease burden and socio-economic costs of these conditions worldwide, drug therapy combined with physical activity can be a useful strate...

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Published inJournal of clinical medicine Vol. 10; no. 15; p. 3442
Main Authors Marini, Sofia, Barone, Giuseppe, Masini, Alice, Dallolio, Laura, Bragonzoni, Laura, Longobucco, Yari, Maffei, Francesca
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 03.08.2021
MDPI
Subjects
Adults
Biomarkers
bone biomarkers
Clinical medicine
Drug dosages
Exercise
Fractures
Metabolism
Older people
Osteoporosis
Passive activity
pharmacological treatment
physical activity
Physical fitness
Prescription drugs
Prevention
Review
Systematic review
training
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Summary:The process of bone loss occurs silently and progressively with age, often appearing as osteopenia or osteoporosis or related fractures. Given the rapid raise in disease burden and socio-economic costs of these conditions worldwide, drug therapy combined with physical activity can be a useful strategy and bone biomarkers, can represent a useful evaluation tool to assess their effects. The objective of this systematic review, conducted according to PRISMA statement, was to investigate the effects of physical activity interventions combined with drug treatments on bone biomarkers in people with osteopenia and osteoporosis. Through PubMed, Cochrane, Cinahl, Embase, Trip, a comprehensive literature search was performed. Each study’s quality was assessed according to the Cochrane risk-of-bias tool. Out of 582 identified articles, 50 full texts were screened. Only one matched the eligibility criteria. The study, scored as high quality, showed, in both experimental and control groups, an increase of CTX and P1NP bone biomarkers, without statistically significant differences. Based on available evidence, no exhaustive conclusion can be drawn. However, this systematic review critically analyses the literature, highlighting the knowledge gap on combined treatments efficacy assessed by bone biomarkers. Moreover, an outlook is provided for the planning of future studies.
Bibliography:ObjectType-Article-2
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ISSN:2077-0383
2077-0383
DOI:10.3390/jcm10153442