Identification of 24-hydroxycholesterol in bovine adrenals in both free and esterified forms and in bovine brains as its sulfate ester

24-Hydroxycholesterol was found to be present in bovine adrenals in a concentration of 2–3μg/kg and in larger amounts (10–12μg/kg) as a saponifiable ester. No solvolyzable sulfate ester was detected. In bovine brains, however, the sulfate ester of this sterol was found in a concentration of 84μg/kg....

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Published inJournal of steroid biochemistry Vol. 21; no. 6; pp. 733 - 736
Main Authors Prasad, V.V.Kris, Ponticorvo, Laura, Lieberman, Seymour
Format Journal Article
LanguageEnglish
Published Oxford Elsevier B.V 01.12.1984
New York, NY Pergamon
Subjects
Adrenal Glands - analysis
Analytical, structural and metabolic biochemistry
Animals
Biological and medical sciences
Brain Chemistry
Cattle
Chemical Phenomena
Chemistry
Fundamental and applied biological sciences. Psychology
Hydroxycholesterols - isolation & purification
Other biological molecules
Sulfuric Acids
Terpenes, steroids. Hormones
Steroid
Vertebrata
Mammalia
Adrenal glands
Free form
Brain (Vertebrata)
Identification
Artiodactyla
Beef
Ungulata
Cholesterol
Bound form
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Summary:24-Hydroxycholesterol was found to be present in bovine adrenals in a concentration of 2–3μg/kg and in larger amounts (10–12μg/kg) as a saponifiable ester. No solvolyzable sulfate ester was detected. In bovine brains, however, the sulfate ester of this sterol was found in a concentration of 84μg/kg. A procedure for the synthesis of [7- 3H] 24S-hydroxycholesterol is described.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0022-4731
DOI:10.1016/0022-4731(84)90038-4