A Wireless Bio-MEMS Sensor for C-Reactive Protein Detection Based on Nanomechanics

• Published in: IEEE transactions on biomedical engineering Vol. 56; no. 2; pp. 462 - 470
• Main Authors: Chen, Chun-Hao, Hwang, Rong-Zhang, Huang, Long-Sun, Lin, Shi-Ming, Chen, Hsiao-Chin, Yang, Yu-Che, Lin, Yu-Tso, Yu, Shih-An, Lin, Yo-Sheng, Wang, Yiao-Hong, Chou, Nai-Kuan, Lu, Shey-Shi
• Format: Journal Article
• Language: English
• Published: United States IEEE 01.02.2009; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Amplitude shift keying; amplitude-shift-keying (ASK) receiver; Analog-to-digital converter (ADC); antiCRP; ASK transmitter; Biosensing Techniques - instrumentation; Biosensors; C-reactive protein (CRP); C-Reactive Protein - analysis; Cardiovascular Diseases - diagnosis; CMOS integrated circuits; CMOS process; Dimethylpolysiloxanes - chemistry; Equipment Design; Equipment Reuse; Humans; label-free; Micro-Electrical-Mechanical Systems - instrumentation; microcantilever; microcontrol unit (MCU); Microelectromechanical systems; Micromechanical devices; Monitoring, Ambulatory - instrumentation; Nanotechnology - instrumentation; poly-dimethyl-siloxane (PDMS); Position sensitive particle detectors; Proteins; Signal Processing, Computer-Assisted - instrumentation; Transceivers; Wireless sensor networks

A quick wireless label-free detection of disease-related C-reactive proteins (CRPs) using a 200-mum-long microelectromechanical systems (MEMS) microcantilever housed in a 7times7 mm 2 reaction chamber with a safe reusable feature is reported. The assay time ranges from about 30 min to 3 h, depending...