A Wireless Bio-MEMS Sensor for C-Reactive Protein Detection Based on Nanomechanics

• Published in: IEEE transactions on biomedical engineering Vol. 56; no. 2; pp. 462 - 470
• Main Authors: Chen, Chun-Hao, Hwang, Rong-Zhang, Huang, Long-Sun, Lin, Shi-Ming, Chen, Hsiao-Chin, Yang, Yu-Che, Lin, Yu-Tso, Yu, Shih-An, Lin, Yo-Sheng, Wang, Yiao-Hong, Chou, Nai-Kuan, Lu, Shey-Shi
• Format: Journal Article
• Language: English
• Published: United States IEEE 01.02.2009; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Amplitude shift keying; amplitude-shift-keying (ASK) receiver; Analog-to-digital converter (ADC); antiCRP; ASK transmitter; Biosensing Techniques - instrumentation; Biosensors; C-reactive protein (CRP); C-Reactive Protein - analysis; Cardiovascular Diseases - diagnosis; CMOS integrated circuits; CMOS process; Dimethylpolysiloxanes - chemistry; Equipment Design; Equipment Reuse; Humans; label-free; Micro-Electrical-Mechanical Systems - instrumentation; microcantilever; microcontrol unit (MCU); Microelectromechanical systems; Micromechanical devices; Monitoring, Ambulatory - instrumentation; Nanotechnology - instrumentation; poly-dimethyl-siloxane (PDMS); Position sensitive particle detectors; Proteins; Signal Processing, Computer-Assisted - instrumentation; Transceivers; Wireless sensor networks
• ISSN: 0018-9294; 1558-2531
• DOI: 10.1109/TBME.2008.2003262

A quick wireless label-free detection of disease-related C-reactive proteins (CRPs) using a 200-mum-long microelectromechanical systems (MEMS) microcantilever housed in a 7times7 mm 2 reaction chamber with a safe reusable feature is reported. The assay time ranges from about 30 min to 3 h, depending on accuracy. The deflection of the microcantilever due to specific CRP-antiCRP binding is detected using a position-sensitive detector. The converted bio-signal is transmitted by a custom designed wireless amplitude-shift-keying (ASK) transceiver IC fabricated in a 0.18 mum CMOS process. CRP concentrations from 1 mug/mL to 500 mug/mL can be detected. A 0.2-Hz 1-V ac signal instead of traditional bases/acids is applied to the bio-MEMS sensor to unbind the CRP from the microcantilever for reusability.