Detectability of auditory evoked response components in preterm infants

• Published in: Early human development Vol. 26; no. 2; pp. 129 - 141
• Main Authors: Pasman, Jaco W., Rotteveel, Jan J., de Graaf, Ruurd, Maassen, Ben, Notermans, Servaas L.H.
• Format: Journal Article
• Language: English
• Published: Lausanne Elsevier Ireland Ltd 01.08.1991; New York,NY Elsevier; Amsterdam
• Subjects: ABR; ACR; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Auditory Cortex - physiology; auditory evoked responses; Auditory Pathways - physiology; Biological and medical sciences; detectability; Emergency and intensive care: neonates and children. Prematurity. Sudden death; Evoked Potentials, Auditory; Evoked Potentials, Auditory, Brain Stem; Humans; Infant, Newborn; Infant, Premature - physiology; Intensive care medicine; Longitudinal Studies; maturation; Medical sciences; MLR; preterm infants; Sensitivity and Specificity; ACR; ABR; MLR; maturation; preterm infants; detectability; auditory evoked responses; Performance evaluation; Human; Premature; Detectability; Newborn diseases; Auditory evoked potential
• ISSN: 0378-3782; 1872-6232
• DOI: 10.1016/0378-3782(91)90017-W

In determining the detectability of brainstem, middle latency and cortical auditory evoked responses in preterm newborns, one has to deal with the ongoing maturation of the auditory system. In the preterm period the detectability of evoked responses is closely related to the appearance of the individual evoked response components. The detectability of the individual evoked response components in preterm infants is important, because low detectability rates make the absence of a particular evoked response component irrelevant with respect to the clinical-neurophysiological correlation. In a longitudinal study we determined the detectability and cumulative detectability, i.e. the presence of individual evoked response components in one or more recordings of evoked response components in 37 low risk preterm infants between 30 and 41 weeks conceptional age (CA). On the basis of their detectability it is concluded that evoked response components, determined between 30 and 34 weeks CA, are generally of limited use for clinical application, except for auditory brainstem response (ABR) components I, IIn, V and Vc and middle latency response (MLR) component Na. Our study made clear that improvement can be achieved by performing more than one examination within a period of approximately 4 weeks between the recording sessions. The cumulative detectability rates after two recordings showed improvement for all components involved in this study. The cumulative detectability rates of ABR components I, II, IIN, III, V, IIc, IIINc, Vc, MLR components Na and P0, and auditory cortical response (ACR) components PbP1 and N2p are sufficient to use as measures in the neurophysiological judgement of functional integrity of the central auditory pathway in preterm infants.