Growth rate determines activity of porphobilinogen deaminase both in nonmalignant and malignant cell lines
PBGD activity and growth rate were determined in cultures of rat embryo fibroblasts, nontransformed and MLV MS transformed fibroblastic cell lines; NIH-3T3 cells, and in a mouse lymphosarcoma cell line [L-929]. The two parameters examined correlate positively ( P < 0.001). The results of this inv...
Saved in:
Published in | Biochemical medicine and metabolic biology Vol. 40; no. 2; pp. 213 - 217 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Boston, MA
Elsevier Inc
01.10.1988
San Diego, CA Academic Press New York, NY |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | PBGD activity and growth rate were determined in cultures of rat embryo fibroblasts, nontransformed and
MLV
MS
transformed fibroblastic cell lines; NIH-3T3 cells, and in a mouse lymphosarcoma cell line [L-929]. The two parameters examined correlate positively (
P < 0.001). The results of this investigation would seem to indicate clearly that porphobilinogen deaminase activity is related to growth. However, these experiments do not rule out the possibility that malignant transformation per se also causes changes in porphobilinogen deaminase activity. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0885-4505 1557-7651 |
DOI: | 10.1016/0885-4505(88)90121-1 |