Roles of YAP/TAZ in ferroptosis

Ferroptosis is a unique iron-dependent form of regulated cell death. Recently, researchers found that ferroptosis was sensitive to cell density, regulated by Hippo signaling. This article summarizes the roles of the Hippo pathway effectors Yes-associated protein (YAP) and transcriptional coactivator...

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Bibliographic Details
Published inTrends in cell biology Vol. 32; no. 9; pp. 729 - 732
Main Authors Magesh, Suchitra, Cai, Danfeng
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.09.2022
Subjects
Adaptor Proteins, Signal Transducing - metabolism
Ferroptosis
Hippo pathway
Humans
Phosphoproteins - metabolism
Signal Transduction
TAZ
Trans-Activators - metabolism
Transcriptional Coactivator with PDZ-Binding Motif Proteins
YAP
YAP-Signaling Proteins
YAP
ferroptosis
Hippo pathway
TAZ
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Summary:Ferroptosis is a unique iron-dependent form of regulated cell death. Recently, researchers found that ferroptosis was sensitive to cell density, regulated by Hippo signaling. This article summarizes the roles of the Hippo pathway effectors Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) in ferroptosis and the therapeutic potential of activating ferroptosis in cancer.
Bibliography:ObjectType-Article-1
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ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2022.05.005