Mifepristone may inhibit the midcycle gonadotropin surge at both ovarian and pituitary sites of action

The ability of mifepristone to delay ovulation is thought to be based on the antigonadotropic effects of the drug. In the current work, late–follicular phase administration of mifepristone resulted in decrease in both circulating FSH and inhibin B, suggesting both central and ovarian sites of action...

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Published inFertility and sterility Vol. 84; no. 5; pp. 1545 - 1546
Main Authors Heikinheimo, Oskari, Leminen, Riikka, Raivio, Taneli
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.11.2005
Elsevier Science
Subjects
Biological and medical sciences
Female
Follicular Phase - blood
Follicular Phase - drug effects
Gonadotropins - blood
Gynecology. Andrology. Obstetrics
Humans
Medical sciences
Mifepristone - pharmacology
Ovary - drug effects
Ovary - metabolism
Pituitary Gland - drug effects
Pituitary Gland - metabolism
Ovary
Endocrine gland
Fertility
Antiprogesterone
Female genital system
Pituitary gland
Mifepristone
Inhibitor
Antihormone
Gonadotropin
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Summary:The ability of mifepristone to delay ovulation is thought to be based on the antigonadotropic effects of the drug. In the current work, late–follicular phase administration of mifepristone resulted in decrease in both circulating FSH and inhibin B, suggesting both central and ovarian sites of action.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0015-0282
1556-5653
DOI:10.1016/j.fertnstert.2005.04.058