Language activation distributions revealed by fMRI in post-operative epilepsy patients: Differences between left- and right-sided resections

• Published in: Epilepsy research Vol. 66; no. 1; pp. 1 - 12
• Main Authors: Backes, W.H., Deblaere, K., Vonck, K., Kessels, A.G., Boon, P., Hofman, P., Wilmink, J.T., Vingerhoets, G., Boon, P.A., Achten, R., Vermeulen, J., Aldenkamp, A.P.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.08.2005; Elsevier
• Subjects: Adult; Anterior temporal lobectomy; Anticonvulsants. Antiepileptics. Antiparkinson agents; Biological and medical sciences; Brain Mapping; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Epilepsy; Epilepsy, Temporal Lobe - physiopathology; Epilepsy, Temporal Lobe - surgery; Female; fMRI; Functional Laterality - physiology; Humans; Image Processing, Computer-Assisted - methods; Language; Magnetic Resonance Imaging; Male; Medical sciences; Middle Aged; Neurology; Neuropharmacology; Oxygen - blood; Pharmacology. Drug treatments; Temporal Lobe - blood supply; Temporal Lobe - surgery; fMRI; Language; Anterior temporal lobectomy; Epilepsy; Human; Temporal lobe; Nervous system diseases; Word; Resection; Temporal lobectomy; Central nervous system; Complex partial epilepsy; Representation; Prefrontal cortex; Nuclear magnetic resonance imaging; Cerebral disorder; Central nervous system disease; Frontal; Temporal lobe epilepsy; Functional imaging
• ISSN: 0920-1211; 1872-6844
• DOI: 10.1016/j.eplepsyres.2005.06.007

To reveal differences of cerebral activation related to language functions in post-operative temporal lobe epilepsy (TLE) patients. Right (RTL) and left temporal lobe (LTL) resected patients, and healthy controls were studied using functional magnetic resonance imaging (fMRI). Only patients with complete left-hemispheric language dominance according to the intracarotid amytal procedure (IAP) were included. Language-related activations were evoked by performing word generation and text reading language tasks. Activation lateralization and temporo-frontal distribution effects were analysed. For word generation, only LTL patients showed reduced left lateralized activation compared to controls, due to a decrease in activation in the left prefrontal cortex and an increase in the right prefrontal cortex. For reading, the left-hemispheric lateralization in RTL patients increased because of enhanced activity in the left prefrontal cortex, whereas for LTL patients the activation became bilaterally distributed over the temporal lobes. Lateralization results between pre-operative IAP and post-operative fMRI were highly discordant. Significant temporo-frontal distribution changes manifested from the reading but not from the word generation task. The cerebral language representation in post-operative LTL epilepsy patients is more bi-hemispherically lateralized than in controls and RTL patients. Post-operative temporo-frontal and interhemispheric redistribution effects, involving contralateral homologuous brain areas, are suggested to contribute to the cerebral reorganisation of language function.