Serotonergic Heterotypic Sprouting in the Unilaterally Dopamine-Depleted Mouse Neostriatum

The effects of unilateral 6-hydroxydopamine (6-OHDA) treatment on striatal serotonin neurons in 12-day-old mice were studied using immunohistochemistry. The unilateral 6-OHDA lesions were evaluated with tyrosine hydroxylase (TH) immunohistochemistry. The majority of the TH-immunoreactive structures...

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Bibliographic Details
Published inDevelopmental neuroscience Vol. 23; no. 1; pp. 78 - 83
Main Authors Yamazoe, Ichiro, Takeuchi, Yoshihiro, Matsushita, Hiroko, Kawano, Hisashi, Sawada, Tadashi
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 01.01.2001
Subjects
Age Factors
Animals
Dopamine - deficiency
Immunohistochemistry
Mice
Mice, Inbred ICR
Neostriatum - cytology
Neostriatum - metabolism
Nerve Degeneration - chemically induced
Nerve Degeneration - metabolism
Neurites - chemistry
Neurites - drug effects
Neurites - enzymology
Original Paper
Oxidopamine
Serotonin - analysis
Serotonin - physiology
Sympatholytics
Tyrosine 3-Monooxygenase - analysis
Immunohistochemistry
Dopamine
Serotonin
Neostriatum
6-Hydroxydopamine
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Summary:The effects of unilateral 6-hydroxydopamine (6-OHDA) treatment on striatal serotonin neurons in 12-day-old mice were studied using immunohistochemistry. The unilateral 6-OHDA lesions were evaluated with tyrosine hydroxylase (TH) immunohistochemistry. The majority of the TH-immunoreactive structures disappeared from the substantia nigra and neostriatum on the 6-OHDA lesioned side. However, the density of serotonin fibers was markedly increased throughout the 6-OHDA-depleted neostriatum 1 year later. These results suggest that serotonergic heterotypic sprouting may be permanent.
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ISSN:0378-5866
1421-9859
DOI:10.1159/000048698