The clinical course and outcomes of non-aneurysmal subarachnoid hemorrhages in a single-center retrospective study

• Published in: Acta neurochirurgica Vol. 165; no. 10; pp. 2843 - 2853
• Main Authors: Tarkiainen, Jeremias, Hovi, Valtteri, Pyysalo, Liisa, Ronkainen, Antti, Frösen, Juhana
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.10.2023; Springer Nature B.V
• Subjects: Aneurysm; Bleeding; Hydrocephalus; Interventional Radiology; Medical records; Medicine; Medicine & Public Health; Minimally Invasive Surgery; Neurology; Neuroradiology; Neurosurgery; Original; Original Article; Patients; Regression analysis; Risk factors; Surgical Orthopedics; Vascular Neurosurgery – Other; Vasoconstriction; Loss of consciousness; Vasospasm; Non-aneurysmal subarachnoid hemorrhage; Hydrocephalus; Outcome
• ISSN: 0942-0940; 0001-6268; 0942-0940
• DOI: 10.1007/s00701-023-05767-4

Background Non-aneurysmal subarachnoid hemorrhages (SAHs) are thought to have a benign clinical course compared to aneurysmal SAHs. The aim of this study is to report the clinical course and outcomes of non-aneurysmal SAHs in a large single-center study. Methods The patients with non-aneurysmal SAHs were screened from Tampere University Hospital from 2005 to 2020. The clinical data were collected from the patient’s medical records and from the imaging studies. The primary interest was the neurological outcome assessed by dichotomized GOS at 2 months. Multivariable logistic regression was used to study the factors associated with unfavorable outcome. Results We found 216 non-aneurysmal SAHs in 214 patients (2 patients with > 1 bleed). Ninety-seven percent of patients with a typical perimesencephalic bleeding pattern SAH (PSAH) (75/77) had a favorable outcome, while 86% of patients with non-perimesencephalic SAH (NPSAH) had a favorable outcome (84/98). In a multivariable logistic regression analysis, loss of consciousness (LOC) (aOR 214.67, 95% CI 17.62–2615.89) and Fisher grade 4 bleeding pattern (aOR 23.32, 95% CI 1.40–387.98) were associated with increased risk for unfavorable outcome (GOS 1–3). Vasospasm was seen in 20% of non-aneurysmal SAH patients, hydrocephalus in 17%, and 13% needed ventriculostomy. Conclusions Non-aneurysmal SAH seems to have a good prognosis for majority of patients, especially for patients with a PSAH. Non-aneurysmal SAH patients are however affected by vasospasm and hydrocephalus and have similar risk factors for poor outcome as patients with aneurysmal SAH. This suggests that it is the severity of the bleed rather than the etiology that associates with poor outcome.