Solid-state NMR and IR for the analysis of pharmaceutical solids: polymorphs of fosinopril sodium

The two polymorphic modifications of fosinopril sodium have been characterized as to their differences in melting behaviour, powder X-ray diffraction patterns, Fourier transform infrared spectra (FTIR), and solid-state 31P- and 13C-NMR spectra. The polymorphs were found to be enantiotropically relat...

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Bibliographic Details
Published inJournal of pharmaceutical and biomedical analysis Vol. 11; no. 11-12; p. 1063
Main Authors Brittain, H G, Morris, K R, Bugay, D E, Thakur, A B, Serajuddin, A T
Format Journal Article
LanguageEnglish
Published England 1993
Subjects
Crystallization
Fosinopril - analysis
Magnetic Resonance Spectroscopy
Spectroscopy, Fourier Transform Infrared
Stereoisomerism
X-Ray Diffraction
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Summary:The two polymorphic modifications of fosinopril sodium have been characterized as to their differences in melting behaviour, powder X-ray diffraction patterns, Fourier transform infrared spectra (FTIR), and solid-state 31P- and 13C-NMR spectra. The polymorphs were found to be enantiotropically related based upon melting point, heat of fusion, and solution mediated transformation data. Analysis of the solid-state FTIR and 13C-NMR data indicated that the environment of the acetal side chain of fosinopril sodium differed in two polymorphs, and that there might be cis-trans isomerization about the C6-N peptide bond. These conformational differences are postulated as the origin of the observed polymorphism.
ISSN:0731-7085
DOI:10.1016/0731-7085(93)80083-D