Assessing health-related quality of life in patients with Parkinson's disease in a prospective longitudinal study

• Published in: Parkinsonism & related disorders Vol. 13; no. 2; pp. 108 - 114
• Main Authors: Reuther, M, Spottke, E.A, Klotsche, J, Riedel, O, Peter, H, Berger, K, Athen, O, Köhne-Volland, R, Dodel, R.C
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2007
• Subjects: Adult; Aged; Aged, 80 and over; Case-Control Studies; EQ-5D; Female; Health Status; Humans; Longitudinal Studies; Male; Middle Aged; Neurology; Outcome; Parkinson Disease - physiopathology; Parkinson Disease - psychology; Parkinson's disease; PDQ-39; PDQL; Psychometrics; Quality of Life; Severity of Illness Index; Sickness Impact Profile; PDQ-39; EQ-5D; PDQL; Parkinson's disease; Outcome; Quality of life
• ISSN: 1353-8020; 1873-5126
• DOI: 10.1016/j.parkreldis.2006.07.009

Abstract Objective To prospectively assess the health-related quality of life (HrQoL) in Parkinson's disease (PD) during 12 months. Methods HrQoL was assessed in 145 PD patients using the PD-specific PDQ-39, PDQL and the generic EQ-5D. In addition, clinical rating-scales were used. Results All scales showed a pronounced effect of PD. In comparison to an age-matched population the EQ-5D was considerably affected. In comparison to baseline, however, there was no significant change in the generic scale but a significant change in the sum-score of disease-specific HrQoL-scales. Conclusions Only disease-specific scales were sensitive to change. Further studies are necessary to evaluate the time-dependent change in HrQoL.