Abnormal expression of serotonin transporter mRNA in the frontal and temporal cortex of schizophrenics

Postmortem brain tissue was used to measure expression of serotonin transporter mRNA in the left frontal and left temporal cortex from schizophrenics (n = 24) and from normal control individuals with no history of psychiatric illness (n = 10). There was an approximately four-fold increase of seroton...

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Bibliographic Details
Published inMolecular psychiatry Vol. 2; no. 1; pp. 57 - 64
Main Authors Hernandez, I, Sokolov, B P
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.01.1997
Subjects
Aged
Aged, 80 and over
Antipsychotics
Autopsy
Brodmann's area
Carrier Proteins - metabolism
Cortex (frontal)
Cortex (temporal)
Female
Frontal Lobe - metabolism
Gene expression
Humans
Male
Membrane Glycoproteins - metabolism
Membrane Transport Proteins
Mental disorders
Middle Aged
mRNA
Nerve Tissue Proteins
Polymerase Chain Reaction
RNA, Messenger - metabolism
Schizophrenia
Schizophrenia - metabolism
Serotonin
Serotonin Plasma Membrane Transport Proteins
Serotonin transporter
Temporal Lobe - metabolism
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Summary:Postmortem brain tissue was used to measure expression of serotonin transporter mRNA in the left frontal and left temporal cortex from schizophrenics (n = 24) and from normal control individuals with no history of psychiatric illness (n = 10). There was an approximately four-fold increase of serotonin transporter mRNA in Brodmann's area 9 and a two-fold decrease in Brodmann's areas 21 and 22. The changes in serotonin transporter mRNA were more prominent in schizophrenics who had received neuroleptic drugs within 1 week prior to death than in schizophrenics who were neuroleptic-free for more than 2 weeks prior to death, suggesting that the changes may be related to neuroleptic treatment. There was no correlation between serotonin transporter mRNA levels and the sex or age of schizophrenic and control cases or the postmortem delay intervals. These results support the hypothesis that region-specific changes in serotonin transporter expression occur in brains of some schizophrenics. Future studies are necessary to determine whether the changes in serotonin transporter expression are drug-related or are associated with the illness itself.
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ISSN:1359-4184
1476-5578
DOI:10.1038/sj.mp.4000215