Bone mineral density in short bowel syndrome: correlation with BMI and serum vitamins C, E and K

• Published in: Archives of Endocrinology and Metabolism Vol. 59; no. 3; pp. 252 - 258
• Main Authors: Braga, Camila Bitu Moreno, Bizari, Letícia, Suen, Vivian Miguel Marques, Marchini, Júlio Sérgio, Paula, Francisco José Albuquerque de, Cunha, Selma Freire de Carvalho da
• Format: Journal Article
• Language: English
• Published: Brazil Brazilian Society of Endocrinology and Metabolism 01.06.2015
• Subjects: Absorptiometry, Photon; Adult; Aged; Ascorbic Acid - blood; Avitaminosis - complications; Body Mass Index; bone density; Bone Density - physiology; Bone Diseases, Metabolic - etiology; Calcium - analysis; Cross-Sectional Studies; Energy Intake - physiology; Female; Hospitalization; Humans; Male; Middle Aged; minerals; Osteoporosis - etiology; Phosphorus - analysis; Reference Values; Short bowel syndrome; Short Bowel Syndrome - blood; Short Bowel Syndrome - complications; Short Bowel Syndrome - physiopathology; Time Factors; Vitamin E - blood; Vitamin K - blood; vitamins
• ISSN: 2359-3997; 2359-4292; 2359-4292; 2359-3997
• DOI: 10.1590/2359-3997000000046

Bone loss has been established as a major extra-intestinal complication of short bowel syndrome (SBS). The purpose of this study was to correlate bone mineral density (BMD) with body mass index (BMI), serum vitamin and mineral levels in patients with SBS. The study was conducted on 13 patients (8 male and 5 female, 54.7 ± 11.4 years) with SBS (residual small bowel length of 10 to 100 cm). We determined the food ingestion, anthropometry, serum levels of vitamins C, A, D, E and K, as well as serum and urinary levels of phosphorus and calcium. BMD was measured by dual-energy x-ray absorptiometry (DXA). Osteopenia and osteoporosis was diagnosed in all but one SBS patient. Serum levels of vitamin D were low in all volunteers. Sixty-one percent of patients had vitamin E deficiency; hypovitaminosis A and C occurred in one subject. BMI and C, E and K vitamin serum levels correlated with T-score of BMD. Osteopenia and osteoporosis were common in SBS patients. There was a correlation between BMD and the serum levels of vitamins C, E and K, an indicative that such vitamins may influence bone health.